GDF15 expression in glioma is associated with malignant progression, immune microenvironment, and serves as a prognostic factor.

ABSTRACT:

Aims

Growth differentiation factor 15 (GDF15) is involved in lots of crucial inflammatory and immune response. The clinical and immune features for GDF15 in glioma have not been specifically investigated so far.

Methods

Gene expression profiles obtained from public glioma datasets were used to explore the biological function of GDF15 and its impact on immune microenvironment. Interference with GDF15 in several glioma cell lines to verify its functions in vitro. Survival data were used for the survival analysis and establishment of a nomogram predictive model.

Results

GDF15 was up-regulated in various malignant phenotypes of glioma. Function analysis and in vitro experiments revealed that GDF15 was associated with malignant progression and NF-κB pathway. GDF15 was clos

SUBMITTER: Guo L 

PROVIDER: S-EPMC8673705 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature