Ontology highlight
ABSTRACT:
SUBMITTER: Lin WS
PROVIDER: S-EPMC8674692 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Lin Wei-Shuo WS Chen I-Chen IC Chen Hui-Chen HC Lee Yi-Chien YC Wu Suh-Chin SC
Frontiers in immunology 20211202
Glycan-masking the vaccine antigen by mutating the undesired antigenic sites with an additional <i>N</i>-linked glycosylation motif can refocus B-cell responses to desired epitopes, without affecting the antigen's overall-folded structure. This study examined the impact of glycan-masking mutants of the N-terminal domain (NTD) and receptor-binding domain (RBD) of SARS-CoV-2, and found that the antigenic design of the S protein increases the neutralizing antibody titers against the Wuhan-Hu-1 ance ...[more]