Comprehensive analysis of ceRNA network of ERCC4 in colorectal cancer.

ABSTRACT:

Objective

ERCC4 is one of the most significant molecules of Nucleotide Excision Repair (NER), which has been researched due to its high expression in colorectal cancer (CRC). This study aimed to find out the ceRNA (competitive endogenous RNA) network of ERCC4 in CRC.

Methods and materials

Pan cancer mRNA expression of ERCC4 was evaluated using TCGA database. The protein expression of ERCC4 was evaluated based on the Human Protein Atlas (HPA). We screened DElncRNAs and DEmiRNAs in two groups of ERCC4 ^high and ERCC4 ^low expression in CRC. Then a lncRNA-miRNA-ERCC4 regulatory network was constructed based on DElncRNAs and DEmiRNAs using Starbase database and visualized by Cytoscape software. Kaplan-Meier analysis was perf

SUBMITTER: Hu H 

PROVIDER: S-EPMC8679902 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature