Complexities in the role of acetylation dynamics in modifying inducible gene activation parameters.

ABSTRACT: High levels of histone acetylation are associated with the regulatory elements of active genes, suggesting a link between acetylation and gene activation. We revisited this model, in the context of EGF-inducible gene expression and found that rather than a simple unifying model, there are two broad classes of genes; one in which high lysine acetylation activity is required for efficient gene activation, and a second group where the opposite occurs and high acetylation activity is inhibitory. We examined the latter class in more detail using EGR2 as a model gene and found that lysine acetylation levels are critical for several activation parameters, including the timing of expression onset, and overall amplitudes of the transcriptional response. In contrast, DUSP1 responds in the canonical

SUBMITTER: Carrera S 

PROVIDER: S-EPMC8682737 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature