Ontology highlight
ABSTRACT:
SUBMITTER: Dagamajalu S
PROVIDER: S-EPMC8688651 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Dagamajalu Shobha S Rex D A B DAB Philem Pushparani Devi PD Rainey Jan K JK Keshava Prasad T S TS
Journal of cell communication and signaling 20210402 1
The apelin receptor (APLNR) is a class A (rhodopsin-like) G-protein coupled receptor with a wide distribution throughout the human body. Activation of the apelin/APLNR system regulates AMPK/PI3K/AKT/mTOR and RAF/ERK1/2 mediated signaling pathways. APLNR activation orchestrates several downstream signaling cascades, which play diverse roles in physiological effects, including effects upon vasoconstriction, heart muscle contractility, energy metabolism regulation, and fluid homeostasis angiogenesi ...[more]