Comprehensive network map of interferon gamma signaling.

ABSTRACT: Interferon gamma (IFN-?), is a cytokine, which is an important regulator of host defense system by mediating both innate and adaptive immune responses. IFN-? signaling is primarily associated with inflammation and cell-mediated immune responses. IFN-? is also represented as antitumor cytokine which facilitates immunosurveillance in tumor cells. In addition, IFN-? mediated signaling also elicits pro-tumorigenic transformations and promotes tumor progression. Impact of IFN-? signaling in mammalian cells has been widely studied which indicate that IFN-? orchestrates distinct cellular functions including immunomodulation, leukocyte trafficking, apoptosis, anti-microbial, and both anti- and pro-tumorigenic role. However, a detailed network of IFN-? signaling pathway is currently lacking. Therefore, we systematically curated the literature information pertaining to IFN-? signaling and develop a comprehensive signaling network to facilitate better understanding of IFN-? mediated signaling. A total of 124 proteins were catalogued that were experimentally proven to be involved in IFN-? signaling cascade. These 124 proteins were found to participate in 81 protein-protein interactions, 94 post-translational modifications, 20 translocation events, 54 activation/inhibiton reactions. Further, 236 differential expressed genes were also documented in IFN-? mediated signaling. IFN-? signaling pathway is made freely available to scientific audience through NetPath at ( http://www.netpath.org/pathways?path_id=NetPath_32 ). We believe that documentation of reactions pertaining to IFN-? signaling and development of pathway map will facilitate further research in IFN-? associated human diseases including cancer.

SUBMITTER: Bhat MY 

PROVIDER: S-EPMC6235777 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature