Association Between Genetic Predictors for C-Reactive Protein and Venous Thromboembolism With Severe Adverse Coronavirus Disease 2019 Outcomes.

ABSTRACT: To assess if genetic predictors for C-reactive protein and risk of venous thromboembolism are associated with severe outcomes among individuals who tested positive for severe acute respiratory syndrome coronavirus 2.

Design

Retrospective cohort study.

Setting

U.K. Biobank.

Patients or subjects

U.K. Biobank participants with European ancestry who were recorded to have a positive polymerase chain reaction test result for severe acute respiratory syndrome coronavirus 2 between March 16, 2020, and August 14, 2020.

Interventions

Not applicable.

Measurements and main results

We constructed separate genetic risk scores for C-reactive protein and venous thromboembolism consisting of 56 and 37 genetic variants that have been significantly associated with venous th

SUBMITTER: Guo B 

PROVIDER: S-EPMC8691492 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature