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Theoretical investigation on the effect of terahertz wave on Ca2+ transport in the calcium channel

ABSTRACT: Summary The question of whether terahertz (THz) waves can interact with ions in channels of nerve cells and cause a further reaction has attracted much attention. To answer this question, we investigate the spontaneous radiation generated by Ca2+ moving in calcium channels and the effect of THz radiation on the transport of Ca2+ by solving the mathematical physical model through Brownian dynamics (BD) simulations. It is obtained that the moving Ca2+ in a calcium channel can generate electromagnetic radiation, the corresponding spectrum of which is concentrated in the THz range. Meanwhile, both the ion number in the channel and the background temperature are proved to have significant effects on the spontaneous emission spectra. The studies also show that external THz radiation can accelerate Ca2+ transport through the ion channel. These results are expected to provide a theoretical basis for the future treatment of THz waves in the neurological field. Graphical abstract Highlights • We demonstrate the THz radiation generated by Ca2+ transport in the channel• External THz stimulation can enhance the radiation spectrum of Ca2+• External THz stimulation can accelerate the transport of Ca2+ across the membrane Physics; Theoretical physics; Radiation physics

SUBMITTER: Guo L

PROVIDER: S-EPMC8693466 | biostudies-literature |

REPOSITORIES: biostudies-literature

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