Ontology highlight
ABSTRACT:
SUBMITTER: Ho BX
PROVIDER: S-EPMC8693666 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Ho Beatrice Xuan BX Yu Hongbing H Pang Jeremy Kah Sheng JKS Hor Jin-Hui JH Liew Lee Chuen LC Szyniarowski Piotr P Lim Christina Ying Yan CYY An Omer O Yang Henry He HH Stewart Colin L CL Chan Woon Khiong WK Ng Shi-Yan SY Soh Boon-Seng BS
Stem cell reports 20211111 12
The immature characteristics and metabolic phenotypes of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) restrict their applications for disease modeling, drug discovery, and cell-based therapy. Leveraging on the metabolic shifts from glycolysis to fatty acid oxidation as CMs mature, a human hexokinase1-GFP metabolic reporter cell line (H7 HK1-GFP) was generated to facilitate the isolation of fetal or more matured hPSC-CMs. RNA sequencing of fetal versus more matured CMs uncovered ...[more]