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Topical treatments for scalp psoriasis.

ABSTRACT:

SUBMITTER: Schlager JG

PROVIDER: S-EPMC8697570 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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Topical treatments for scalp psoriasis.

Schlager Justin Gabriel JG Rosumeck Stefanie S Werner Ricardo Niklas RN Jacobs Anja A Schmitt Jochen J Schlager Christoph C Nast Alexander A

The Cochrane database of systematic reviews 20160226

<h4>Background</h4>People with chronic plaque psoriasis often have lesions on the scalp. Hair makes the scalp difficult to treat and the adjacent facial skin is particularly sensitive to topical treatments.<h4>Objectives</h4>To assess the efficacy and safety of topical treatments for scalp psoriasis.<h4>Search methods</h4>We searched the following databases up to August 2015: the Cochrane Skin Group Specialised Register, CENTRAL (2015, Issue 7), MEDLINE (from 1946), EMBASE (from 1974) and LILACS ...[more]

PMID: 26915340

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Molecular and cellular profilling of scalp psoriasis reveals differences and similarities compared to skin psoriasis

Project description:Scalp psoriasis shows a variable clinical spectrum and in many cases poses a great therapeutic challenge. However, it remains unknown whether the immune response of scalp psoriasis differs from understood pathomechanisms of psoriasis on other skin areas. We sought to determine the cellular and mollecular phenotype of scalp psoriasis by performing a comparative analysis of scalp vs skin using lesional and nonlesional samples from 20 Caucasian subjects with untreated moderate to severe psoriasis and significant scalp involvement, and 10 control subjects without psoriasis. Our results suggest that even in the scalp psoriasis is a disease of the inter-follicular skin. The immune mechanisms that mediate scalp psoriasis were found to be similar to those involved in skin psoriasis. However, the magnitude of dysregulation, number of differentially expressed genes, and enrichment of the psoriatic genomic fingerprinting were more prominent in skin lesions. Furthermore, the scalp transcriptome showed increased modulation of several gene-sets, particularly those induced by interferon-gamma, compared with skin psoriasis which was mainly associated with activation of TNF↵/L-17/IL-22-induced keratinocyte response genes. We also detected differences in expression of gene-sets involving negative regulation, epigenetic regulation, epidermal differentiation, and dendritic cell or Th1/Th17/Th22-related T-cell processes.

2015-11-25 | GSE75343 | GEO

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