Planar Boronic Graphene and Nitrogenized Graphene Heterostructure for Protein Stretch and Confinement.

ABSTRACT: Single-molecule techniques such as electron tunneling and atomic force microscopy have attracted growing interests in protein sequencing. For these methods, it is critical to refine and stabilize the protein sample to a "suitable mode" before applying a high-fidelity measurement. Here, we show that a planar heterostructure comprising boronic graphene (BC3) and nitrogenized graphene (C3N) sandwiched stripe (BC3/C3N/BC3) is capable of the effective stretching and confinement of three types of intrinsically disordered proteins (IDPs), including amyloid-β (1-42), polyglutamine (Q42), and α-Synuclein (61-95). Our molecular dynamics simulations demonstrate that the protein molecules interact more strongly with the C3N stripe than the BC3 one, which leads to their capture, elongation, and confine

SUBMITTER: Su X 

PROVIDER: S-EPMC8698321 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature