Ontology highlight
ABSTRACT:
SUBMITTER: Ancona S
PROVIDER: S-EPMC8698908 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Ancona Silvia S Orpianesi Emanuela E Bernardelli Clara C Chiaramonte Eloisa E Chiaramonte Raffaella R Terraneo Silvia S Di Marco Fabiano F Lesma Elena E
Biomedicines 20211124 12
Matrix metalloproteinase (MMP) dysregulation is implicated in several diseases, given their involvement in extracellular matrix degradation and cell motility. In lymphangioleiomyomatosis (LAM), a pulmonary rare disease, MMP-2 and MMP-9 have been detected at high levels in serum and urine. LAM cells, characterized by a mutation in the tuberous sclerosis complex (TSC)1 or TSC2, promote cystic lung destruction. The role of MMPs in invasive and destructive LAM cell capability has not yet been fully ...[more]