Ontology highlight
ABSTRACT:
SUBMITTER: Fovez Q
PROVIDER: S-EPMC8699320 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Fovez Quentin Q Laine William W Goursaud Laure L Berthon Celine C Germain Nicolas N Degand Claire C Sarry Jean-Emmanuel JE Quesnel Bruno B Marchetti Philippe P Kluza Jerome J
Cancers 20211217 24
Resistant acute myeloid leukemia (AML) exhibits mitochondrial energy metabolism changes compared to newly diagnosed AML. This phenotype is often observed by evaluating the mitochondrial oxygen consumption of blasts, but most of the oximetry protocols were established from leukemia cell lines without validation on primary leukemia cells. Moreover, the cultures and storage conditions of blasts freshly extracted from patient blood or bone marrow cause stress, which must be evaluated before determin ...[more]