Ontology highlight
ABSTRACT:
SUBMITTER: Rajagopal MU
PROVIDER: S-EPMC8699757 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Rajagopal Meena U MU Bansal Shivani S Kaur Prabhjit P Jain Shreyans K SK Altadil Tatiana T Hinzman Charles P CP Li Yaoxiang Y Moulton Joanna J Singh Baldev B Bansal Sunil S Chauthe Siddheshwar Kisan SK Singh Rajbir R Banerjee Partha P PP Mapstone Mark M Fiandaca Massimo S MS Federoff Howard J HJ Unger Keith K Smith Jill P JP Cheema Amrita K AK
Cancers 20211209 24
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy wherein a majority of patients present metastatic disease at diagnosis. Although the role of epithelial to mesenchymal transition (EMT), mediated by transforming growth factor beta (TGFβ), in imparting an aggressive phenotype to PDAC is well documented, the underlying biochemical pathway perturbations driving this behaviour have not been elucidated. We used high-resolution mass spectrometry (HRMS) based molecular phenotyping a ...[more]