Ontology highlight
ABSTRACT:
SUBMITTER: Gyuricza B
PROVIDER: S-EPMC8703807 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Gyuricza Barbara B Szabó Judit P JP Arató Viktória V Dénes Noémi N Szűcs Ágnes Á Berta Katalin K Kis Adrienn A Szücs Dániel D Forgács Viktória V Szikra Dezső D Kertész István I Trencsényi György G Fekete Anikó A
Pharmaceutics 20211207 12
Tumor hypoxia induces angiogenesis, which is required for tumor cell survival. The aminopeptidase N receptor (APN/CD13) is an excellent marker of angiogenesis since it is overexpressed in angiogenic blood vessels and in tumor cells. Asparagine-glycine-arginine (NGR) peptide analogs bind selectively to the APN/CD13 recepto, therefore, they are important vector molecules in the development of a PET radiotracer which is capable of detecting APN-rich tumors. To investigate the effect of glycosylatio ...[more]