Ontology highlight
ABSTRACT:
SUBMITTER: Pippin AB
PROVIDER: S-EPMC5733259 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Pippin Adam B AB Voll Ronald J RJ Li Yuancheng Y Wu Hui H Mao Hui H Goodman Mark M MM
ACS medicinal chemistry letters 20171115 12
The endogenous amino acid, 5-aminolevulinic acid (5-ALA), has received significant attention as an imaging agent, including ongoing clinical trials for image-guided tumor resection due to its selective uptake and subsequent accumulation of the fluorescent protoporphyrin IX in tumor cells. Based on the widely reported selectivity of 5-ALA, a new positron emission tomography imaging probe was developed by reacting methyl 5-bromolevulinate with [<sup>13</sup>N] ammonia. The radiotracer, [<sup>13</s ...[more]