Genome-Wide Association Study of Lithium-Induced Dry Mouth in Bipolar I Disorder.

ABSTRACT: Dry mouth is a rather common unpleasant adverse drug reaction (ADR) to lithium treatment in bipolar disorders that often lead to poor adherence or early dropout. The aim of this study was to identify the genetic variants of dry mouth associated with lithium treatment in patients with bipolar I (BPI) disorder. In total, 1242 BPI patients who had ever received lithium treatment were identified by the Taiwan Bipolar Consortium for this study. The proportions of patients who experienced impaired drug compliance during lithium medication were comparable between those only with dry mouth and those with any other ADR (86% and 93%, respectively). Dry mouth appeared to be the most prevalent (47.3%) ADR induced by lithium treatment. From the study patients, 921 were included in a genome-wide associa

SUBMITTER: Wu LS 

PROVIDER: S-EPMC8706003 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature