Unknown

Dataset Information

0

ZRC3308 Monoclonal Antibody Cocktail Shows Protective Efficacy in Syrian Hamsters against SARS-CoV-2 Infection.

ABSTRACT: We have developed a monoclonal antibody (mAb) cocktail (ZRC-3308) comprising of ZRC3308-A7 and ZRC3308-B10 in the ratio 1:1 for COVID-19 treatment. The mAbs were designed to have reduced immune effector functions and increased circulation half-life. mAbs showed good binding affinities to non-competing epitopes on RBD of SARS-CoV-2 spike protein and were found neutralizing SARS-CoV-2 variants B.1, B.1.1.7, B.1.351, B.1.617.2, and B.1.617.2 AY.1 in vitro. The mAb cocktail demonstrated effective prophylactic and therapeutic activity against SARS-CoV-2 infection in Syrian hamsters. The antibody cocktail appears to be a promising candidate for prophylactic use and for therapy in early COVID-19 cases that have not progressed to severe disease.

SUBMITTER: Yadav PD 

PROVIDER: S-EPMC8706527 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

We have developed a monoclonal antibody (mAb) cocktail (ZRC-3308) comprising of ZRC3308-A7 and ZRC3308-B10 in the ratio 1:1 for COVID-19 treatment. The mAbs were designed to have reduced immune effector functions and increased circulation half-life. mAbs showed good binding affinities to non-competing epitopes on RBD of SARS-CoV-2 spike protein and were found neutralizing SARS-CoV-2 variants B.1, B.1.1.7, B.1.351, B.1.617.2, and B.1.617.2 AY.1 in vitro. The mAb cocktail demonstrated effective pr  ...[more]

Similar Datasets

Unknown Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy.
| S-EPMC7489885 | biostudies-literature
Unknown Protective efficacy of a SARS-CoV-2 DNA vaccine in wild-type and immunosuppressed Syrian hamsters.
| S-EPMC7835356 | biostudies-literature
Unknown A Potent SARS-CoV-2 Neutralizing Human Monoclonal Antibody That Reduces Viral Burden and Disease Severity in Syrian Hamsters.
| S-EPMC7775388 | biostudies-literature
Unknown SARS-CoV-2 infection induces protective immunity and limits transmission in Syrian hamsters.
| S-EPMC7893819 | biostudies-literature
Unknown Monoclonal Antibody Cocktail Protects Hamsters From Lethal Marburg Virus Infection.
| S-EPMC6249582 | biostudies-literature
Unknown Evaluation of a panel of therapeutic antibody clinical candidates for efficacy against SARS-CoV-2 in Syrian hamsters.
| S-EPMC10060192 | biostudies-literature
Unknown A broadly neutralizing antibody protects Syrian hamsters against SARS-CoV-2 Omicron challenge.
| S-EPMC9223271 | biostudies-literature
Unknown Vaccinia virus-based vaccines confer protective immunity against SARS-CoV-2 virus in Syrian hamsters.
| S-EPMC8428573 | biostudies-literature
Unknown Intranasal delivery of a rationally attenuated SARS-CoV-2 is immunogenic and protective in Syrian hamsters.
| S-EPMC9648440 | biostudies-literature
Transcriptomics Prior influenza infection mitigates SARS-CoV-2 disease in Syrian hamsters
2024-02-05 | GSE254516 | GEO