Ontology highlight
ABSTRACT:
SUBMITTER: Sato R
PROVIDER: S-EPMC8708024 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Sato Risa R Ohmori Kotaro K Umetsu Mina M Takao Masaki M Tano Mitsutoshi M Grant Gerald G Porter Brenda B Bet Anthony A Terasaki Tetsuya T Uchida Yasuo Y
Pharmaceutics 20211209 12
The purpose of the present study was to quantitatively elucidate the levels of protein expression of anti-epileptic-drug (AED) transporters, metabolizing enzymes and tight junction molecules at the blood-brain barrier (BBB) in the focal site of epilepsy patients using accurate SWATH (sequential window acquisition of all theoretical fragment ion spectra) proteomics. Brain capillaries were isolated from focal sites in six epilepsy patients and five normal brains; tryptic digests were produced and ...[more]