Dataset Information

STREM-1 Predicts Disease Severity and Mortality in COVID-19 Patients: Involvement of Peripheral Blood Leukocytes and MMP-8 Activity.

ABSTRACT: Uncontrolled inflammatory responses play a critical role in coronavirus disease (COVID-19). In this context, because the triggering-receptor expressed on myeloid cells-1 (TREM-1) is considered an intrinsic amplifier of inflammatory signals, this study investigated the role of soluble TREM-1 (sTREM-1) as a biomarker of the severity and mortality of COVID-19. Based on their clinical scores, we enrolled COVID-19 positive patients (n = 237) classified into mild, moderate, severe, and critical groups. Clinical data and patient characteristics were obtained from medical records, and their plasma inflammatory mediator profiles were evaluated with immunoassays. Plasma levels of sTREM-1 were significantly higher among patients with severe disease compared to all other groups. Additionally, levels of sTREM-1 showed a significant positive correlation with other inflammatory parameters, such as IL-6, IL-10, IL-8, and neutrophil counts, and a significant negative correlation was observed with lymphocyte counts. Most interestingly, sTREM-1 was found to be a strong predictive biomarker of the severity of COVID-19 and was related to the worst outcome and death. Systemic levels of sTREM-1 were significantly correlated with the expression of matrix metalloproteinases (MMP)-8, which can release TREM-1 from the surface of peripheral blood cells. Our findings indicated that quantification of sTREM-1 could be used as a predictive tool for disease outcome, thus improving the timing of clinical and pharmacological interventions in patients with COVID-19.

SUBMITTER: da Silva-Neto PV

PROVIDER: S-EPMC8708887 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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sTREM-1 Predicts Disease Severity and Mortality in COVID-19 Patients: Involvement of Peripheral Blood Leukocytes and MMP-8 Activity.

da Silva-Neto Pedro V PV de Carvalho Jonatan C S JCS Pimentel Vinícius E VE Pérez Malena M MM Toro Diana M DM Fraga-Silva Thais F C TFC Fuzo Carlos A CA Oliveira Camilla N S CNS Rodrigues Lilian C LC Argolo Jamille G M JGM Carmona-Garcia Ingryd I Neto Nicola T NT Souza Camila O S COS Fernandes Talita M TM Bastos Victor A F VAF Degiovani Augusto M AM Constant Leticia F LF Ostini Fátima M FM Feitosa Marley R MR Parra Rogerio S RS Vilar Fernando C FC Gaspar Gilberto G GG da Rocha José J R JJR Feres Omar O Frantz Fabiani G FG Gerlach Raquel F RF Maruyama Sandra R SR Russo Elisa M S EMS Viana Angelina L AL Fernandes Ana P M APM Santos Isabel K F M IKFM Bonato Vânia L D VLD Boechat Antonio L AL Malheiro Adriana A Sadikot Ruxana T RT Dias-Baruffi Marcelo M Cardoso Cristina R B CRB Faccioli Lúcia H LH Sorgi Carlos A CA On Behalf Of The Imunocovid Study Group

Viruses 20211215 12

Uncontrolled inflammatory responses play a critical role in coronavirus disease (COVID-19). In this context, because the triggering-receptor expressed on myeloid cells-1 (TREM-1) is considered an intrinsic amplifier of inflammatory signals, this study investigated the role of soluble TREM-1 (sTREM-1) as a biomarker of the severity and mortality of COVID-19. Based on their clinical scores, we enrolled COVID-19 positive patients (<i>n</i> = 237) classified into mild, moderate, severe, and critical ...[more]

PMID: 34960790

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Dataset Information

STREM-1 Predicts Disease Severity and Mortality in COVID-19 Patients: Involvement of Peripheral Blood Leukocytes and MMP-8 Activity.

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sTREM-1 Predicts Disease Severity and Mortality in COVID-19 Patients: Involvement of Peripheral Blood Leukocytes and MMP-8 Activity.

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