Ontology highlight
ABSTRACT: Objective
To evaluate the association between overweight and obesity on the clinical course and outcomes in patients hospitalized with COVID-19.Design
Retrospective, observational cohort study.Methods
We performed a multicenter, retrospective, observational cohort study of hospitalized COVID-19 patients to evaluate the associations between overweight and obesity on the clinical course and outcomes.Results
Out of 1634 hospitalized COVID-19 patients, 473 (28.9%) had normal weight, 669 (40.9%) were overweight, and 492 (30.1%) were obese. Patients who were overweight or had obesity were younger, and there were more women in the obese group. Normal-weight patients more often had pre-existing conditions such as malignancy, or were organ recipients. During admission, patients who were overweight or had obesity had an increased probability of acute respiratory distress syndrome [OR 1.70 (1.26-2.30) and 1.40 (1.01-1.96)], respectively and acute kidney failure [OR 2.29 (1.28-3.76) and 1.92 (1.06-3.48)], respectively. Length of hospital stay was similar between groups. The overall in-hospital mortality rate was 27.7%, and multivariate logistic regression analyses showed that overweight and obesity were not associated with increased mortality compared to normal-weight patients.Conclusion
In this study, overweight and obesity were associated with acute respiratory distress syndrome and acute kidney injury, but not with in-hospital mortality nor length of hospital stay.
SUBMITTER: van Son J
PROVIDER: S-EPMC8713548 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
van Son Jamie J Oussaada Sabrina M SM Şekercan Aydin A Beudel Martijn M Dongelmans Dave A DA van Assen Sander S Eland Ingo A IA Moeniralam Hazra S HS Dormans Tom P J TPJ van Kalkeren Colin A J CAJ Douma Renée A RA Rusch Daisy D Simsek Suat S Liu Limmie L Kootte Ruud S RS Wyers Caroline E CE IJzerman Richard G RG van den Bergh Joop P JP Stehouwer Coen D A CDA Nieuwdorp Max M Ter Horst Kasper W KW Serlie Mireille J MJ
Frontiers in endocrinology 20211214
<h4>Objective</h4>To evaluate the association between overweight and obesity on the clinical course and outcomes in patients hospitalized with COVID-19.<h4>Design</h4>Retrospective, observational cohort study.<h4>Methods</h4>We performed a multicenter, retrospective, observational cohort study of hospitalized COVID-19 patients to evaluate the associations between overweight and obesity on the clinical course and outcomes.<h4>Results</h4>Out of 1634 hospitalized COVID-19 patients, 473 (28.9%) had ...[more]