Unknown

Dataset Information

0

Discovery of an ancient MHC category with both class I and class II features.


ABSTRACT: Two classes of major histocompatibility complex (MHC) molecules, MHC class I and class II, play important roles in our immune system, presenting antigens to functionally distinct T lymphocyte populations. However, the origin of this essential MHC class divergence is poorly understood. Here, we discovered a category of MHC molecules (W-category) in the most primitive jawed vertebrates, cartilaginous fish, and also in bony fish and tetrapods. W-category, surprisingly, possesses class II-type α- and β-chain organization together with class I-specific sequence motifs for interdomain binding, and the W-category α2 domain shows unprecedented, phylogenetic similarity with β2-microglobulin of class I. Based on the results, we propose a model in which the ancestral MHC class I molecule evolved from class II-type W-category. The discovery of the ancient MHC group, W-category, sheds a light on the long-standing critical question of the MHC class divergence and suggests that class II type came first.

SUBMITTER: Okamura K 

PROVIDER: S-EPMC8713811 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC3260380 | biostudies-literature
| PRJEB15527 | ENA
| S-EPMC3186872 | biostudies-literature
| S-EPMC3077389 | biostudies-literature
| S-EPMC5159193 | biostudies-literature
| S-EPMC7465434 | biostudies-literature
| S-EPMC3085167 | biostudies-literature
| PRJEB19948 | ENA
| S-EPMC7002201 | biostudies-literature
| S-EPMC3009902 | biostudies-other