Ontology highlight
ABSTRACT:
SUBMITTER: Gilchuk P
PROVIDER: S-EPMC8716180 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Gilchuk Pavlo P Murin Charles D CD Cross Robert W RW Ilinykh Philipp A PA Huang Kai K Kuzmina Natalia N Borisevich Viktoriya V Agans Krystle N KN Geisbert Joan B JB Zost Seth J SJ Nargi Rachel S RS Sutton Rachel E RE Suryadevara Naveenchandra N Bombardi Robin G RG Carnahan Robert H RH Bukreyev Alexander A Geisbert Thomas W TW Ward Andrew B AB Crowe James E JE
Cell 20211001 22
Ebolaviruses cause a severe and often fatal illness with the potential for global spread. Monoclonal antibody-based treatments that have become available recently have a narrow therapeutic spectrum and are ineffective against ebolaviruses other than Ebola virus (EBOV), including medically important Bundibugyo (BDBV) and Sudan (SUDV) viruses. Here, we report the development of a therapeutic cocktail comprising two broadly neutralizing human antibodies, rEBOV-515 and rEBOV-442, that recognize non- ...[more]