Ontology highlight
ABSTRACT:
SUBMITTER: Randall JR
PROVIDER: S-EPMC8719016 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Randall Justin R JR Davidson Gillian G Fleeman Renee M RM Acosta Santos A SA Riddington Ian M IM Cole T Jeffrey TJ DuPai Cory D CD Davies Bryan W BW
iScience 20211210 1
The rapid development and spread of antibiotic resistance necessitate the development of novel strategies for antibiotic discovery. Symbah-1, a synthetic peptide antibiotic, was identified in a high-throughput antibacterial screen of random peptide sequences. Symbah-1 functions through membrane disruption and contains broad spectrum bactericidal activity against several drug-resistant pathogens. Circular dichroism and high-resolution mass spectrometry indicate symbah-1 has a β-hairpin structure ...[more]