Dataset Information

Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019.

ABSTRACT:

Importance

The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden.

Objective

To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic Index (SDI) quintiles from 2010 to 2019.

Evidence review

The GBD 2019 estimation methods were used to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs) in 2019 and over the past decade. Estimates are also provided by quintiles of the SDI, a composite measure of educational attainment, income per capita, and total fertility rate for those younger than 25 years. Estimates include 95% uncertainty intervals (UIs).

Findings

In 2019, there were an estimated 23.6 million (95% UI, 22.2-24.9 million) new cancer cases (17.2 million when excluding nonmelanoma skin cancer) and 10.0 million (95% UI, 9.36-10.6 million) cancer deaths globally, with an estimated 250 million (235-264 million) DALYs due to cancer. Since 2010, these represented a 26.3% (95% UI, 20.3%-32.3%) increase in new cases, a 20.9% (95% UI, 14.2%-27.6%) increase in deaths, and a 16.0% (95% UI, 9.3%-22.8%) increase in DALYs. Among 22 groups of diseases and injuries in the GBD 2019 study, cancer was second only to cardiovascular diseases for the number of deaths, years of life lost, and DALYs globally in 2019. Cancer burden differed across SDI quintiles. The proportion of years lived with disability that contributed to DALYs increased with SDI, ranging from 1.4% (1.1%-1.8%) in the low SDI quintile to 5.7% (4.2%-7.1%) in the high SDI quintile. While the high SDI quintile had the highest number of new cases in 2019, the middle SDI quintile had the highest number of cancer deaths and DALYs. From 2010 to 2019, the largest percentage increase in the numbers of cases and deaths occurred in the low and low-middle SDI quintiles.

Conclusions and relevance

The results of this systematic analysis suggest that the global burden of cancer is substantial and growing, with burden differing by SDI. These results provide comprehensive and comparable estimates that can potentially inform efforts toward equitable cancer control around the world.

SUBMITTER: Global Burden of Disease 2019 Cancer Collaboration

PROVIDER: S-EPMC8719276 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019.

Kocarnik Jonathan M JM Compton Kelly K Dean Frances E FE Fu Weijia W Gaw Brian L BL Harvey James D JD Henrikson Hannah Jacqueline HJ Lu Dan D Pennini Alyssa A Xu Rixing R Ababneh Emad E Abbasi-Kangevari Mohsen M Abbastabar Hedayat H Abd-Elsalam Sherief M SM Abdoli Amir A Abedi Aidin A Abidi Hassan H Abolhassani Hassan H Adedeji Isaac Akinkunmi IA Adnani Qorinah Estiningtyas Sakilah QES Advani Shailesh M SM Afzal Muhammad Sohail MS Aghaali Mohammad M Ahinkorah Bright Opoku BO Ahmad Sajjad S Ahmad Tauseef T Ahmadi Ali A Ahmadi Sepideh S Ahmed Rashid Tarik T Ahmed Salih Yusra Y Akalu Gizachew Taddesse GT Aklilu Addis A Akram Tayyaba T Akunna Chisom Joyqueenet CJ Al Hamad Hanadi H Alahdab Fares F Al-Aly Ziyad Z Ali Saqib S Alimohamadi Yousef Y Alipour Vahid V Aljunid Syed Mohamed SM Alkhayyat Motasem M Almasi-Hashiani Amir A Almasri Nihad A NA Al-Maweri Sadeq Ali Ali SAA Almustanyir Sami S Alonso Nivaldo N Alvis-Guzman Nelson N Amu Hubert H Anbesu Etsay Woldu EW Ancuceanu Robert R Ansari Fereshteh F Ansari-Moghaddam Alireza A Antwi Maxwell Hubert MH Anvari Davood D Anyasodor Anayochukwu Edward AE Aqeel Muhammad M Arabloo Jalal J Arab-Zozani Morteza M Aremu Olatunde O Ariffin Hany H Aripov Timur T Arshad Muhammad M Artaman Al A Arulappan Judie J Asemi Zatollah Z Asghari Jafarabadi Mohammad M Ashraf Tahira T Atorkey Prince P Aujayeb Avinash A Ausloos Marcel M Awedew Atalel Fentahun AF Ayala Quintanilla Beatriz Paulina BP Ayenew Temesgen T Azab Mohammed A MA Azadnajafabad Sina S Azari Jafari Amirhossein A Azarian Ghasem G Azzam Ahmed Y AY Badiye Ashish D AD Bahadory Saeed S Baig Atif Amin AA Baker Jennifer L JL Balakrishnan Senthilkumar S Banach Maciej M Bärnighausen Till Winfried TW Barone-Adesi Francesco F Barra Fabio F Barrow Amadou A Behzadifar Masoud M Belgaumi Uzma Iqbal UI Bezabhe Woldesellassie M Mequanint WMM Bezabih Yihienew Mequanint YM Bhagat Devidas S DS Bhagavathula Akshaya Srikanth AS Bhardwaj Nikha N Bhardwaj Pankaj P Bhaskar Sonu S Bhattacharyya Krittika K Bhojaraja Vijayalakshmi S VS Bibi Sadia S Bijani Ali A Biondi Antonio A Bisignano Catherine C Bjørge Tone T Bleyer Archie A Blyuss Oleg O Bolarinwa Obasanjo Afolabi OA Bolla Srinivasa Rao SR Braithwaite Dejana D Brar Amanpreet A Brenner Hermann H Bustamante-Teixeira Maria Teresa MT Butt Nadeem Shafique NS Butt Zahid A ZA Caetano Dos Santos Florentino Luciano FL Cao Yin Y Carreras Giulia G Catalá-López Ferrán F Cembranel Francieli F Cerin Ester E Cernigliaro Achille A Chakinala Raja Chandra RC Chattu Soosanna Kumary SK Chattu Vijay Kumar VK Chaturvedi Pankaj P Chimed-Ochir Odgerel O Cho Daniel Youngwhan DY Christopher Devasahayam J DJ Chu Dinh-Toi DT Chung Michael T MT Conde Joao J Cortés Sanda S Cortesi Paolo Angelo PA Costa Vera Marisa VM Cunha Amanda Ramos AR Dadras Omid O Dagnew Amare Belachew AB Dahlawi Saad M A SMA Dai Xiaochen X Dandona Lalit L Dandona Rakhi R Darwesh Aso Mohammad AM das Neves José J De la Hoz Fernando Pio FP Demis Asmamaw Bizuneh AB Denova-Gutiérrez Edgar E Dhamnetiya Deepak D Dhimal Mandira Lamichhane ML Dhimal Meghnath M Dianatinasab Mostafa M Diaz Daniel D Djalalinia Shirin S Do Huyen Phuc HP Doaei Saeid S Dorostkar Fariba F Dos Santos Figueiredo Francisco Winter FW Driscoll Tim Robert TR Ebrahimi Hedyeh H Eftekharzadeh Sahar S El Tantawi Maha M El-Abid Hassan H Elbarazi Iffat I Elhabashy Hala Rashad HR Elhadi Muhammed M El-Jaafary Shaimaa I SI Eshrati Babak B Eskandarieh Sharareh S Esmaeilzadeh Firooz F Etemadi Arash A Ezzikouri Sayeh S Faisaluddin Mohammed M Faraon Emerito Jose A EJA Fares Jawad J Farzadfar Farshad F Feroze Abdullah Hamid AH Ferrero Simone S Ferro Desideri Lorenzo L Filip Irina I Fischer Florian F Fisher James L JL Foroutan Masoud M Fukumoto Takeshi T Gaal Peter Andras PA Gad Mohamed M MM Gadanya Muktar A MA Gallus Silvano S Gaspar Fonseca Mariana M Getachew Obsa Abera A Ghafourifard Mansour M Ghashghaee Ahmad A Ghith Nermin N Gholamalizadeh Maryam M Gilani Syed Amir SA Ginindza Themba G TG Gizaw Abraham Tamirat T ATT Glasbey James C JC Golechha Mahaveer M Goleij Pouya P Gomez Ricardo Santiago RS Gopalani Sameer Vali SV Gorini Giuseppe G Goudarzi Houman H Grosso Giuseppe G Gubari Mohammed Ibrahim Mohialdeen MIM Guerra Maximiliano Ribeiro MR Guha Avirup A Gunasekera D Sanjeeva DS Gupta Bhawna B Gupta Veer Bala VB Gupta Vivek Kumar VK Gutiérrez Reyna Alma RA Hafezi-Nejad Nima N Haider Mohammad Rifat MR Haj-Mirzaian Arvin A Halwani Rabih R Hamadeh Randah R RR Hameed Sajid S Hamidi Samer S Hanif Asif A Haque Shafiul S Harlianto Netanja I NI Haro Josep Maria JM Hasaballah Ahmed I AI Hassanipour Soheil S Hay Roderick J RJ Hay Simon I SI Hayat Khezar K Heidari Golnaz G Heidari Mohammad M Herrera-Serna Brenda Yuliana BY Herteliu Claudiu C Hezam Kamal K Holla Ramesh R Hossain Md Mahbub MM Hossain Mohammad Bellal Hossain MBH Hosseini Mohammad-Salar MS Hosseini Mostafa M Hosseinzadeh Mehdi M Hostiuc Mihaela M Hostiuc Sorin S Househ Mowafa M Hsairi Mohamed M Huang Junjie J Hugo Fernando N FN Hussain Rabia R Hussein Nawfal R NR Hwang Bing-Fang BF Iavicoli Ivo I Ibitoye Segun Emmanuel SE Ida Fidelia F Ikuta Kevin S KS Ilesanmi Olayinka Stephen OS Ilic Irena M IM Ilic Milena D MD Irham Lalu Muhammad LM Islam Jessica Y JY Islam Rakibul M RM Islam Sheikh Mohammed Shariful SMS Ismail Nahlah Elkudssiah NE Isola Gaetano G Iwagami Masao M Jacob Louis L Jain Vardhmaan V Jakovljevic Mihajlo B MB Javaheri Tahereh T Jayaram Shubha S Jazayeri Seyed Behzad SB Jha Ravi Prakash RP Jonas Jost B JB Joo Tamas T Joseph Nitin N Joukar Farahnaz F Jürisson Mikk M Kabir Ali A Kahrizi Danial D Kalankesh Leila R LR Kalhor Rohollah R Kaliyadan Feroze F Kalkonde Yogeshwar Y Kamath Ashwin A Kameran Al-Salihi Nawzad N Kandel Himal H Kapoor Neeti N Karch André A Kasa Ayele Semachew AS Katikireddi Srinivasa Vittal SV Kauppila Joonas H JH Kavetskyy Taras T Kebede Sewnet Adem SA Keshavarz Pedram P Keykhaei Mohammad M Khader Yousef Saleh YS Khalilov Rovshan R Khan Gulfaraz G Khan Maseer M Khan Md Nuruzzaman MN Khan Moien A B MAB Khang Young-Ho YH Khater Amir M AM Khayamzadeh Maryam M Kim Gyu Ri GR Kim Yun Jin YJ Kisa Adnan A Kisa Sezer S Kissimova-Skarbek Katarzyna K Kopec Jacek A JA Koteeswaran Rajasekaran R Koul Parvaiz A PA Koulmane Laxminarayana Sindhura Lakshmi SL Koyanagi Ai A Kucuk Bicer Burcu B Kugbey Nuworza N Kumar G Anil GA Kumar Narinder N Kumar Nithin N Kurmi Om P OP Kutluk Tezer T La Vecchia Carlo C Lami Faris Hasan FH Landires Iván I Lauriola Paolo P Lee Sang-Woong SW Lee Shaun Wen Huey SWH Lee Wei-Chen WC Lee Yo Han YH Leigh James J Leong Elvynna E Li Jiarui J Li Ming-Chieh MC Liu Xuefeng X Loureiro Joana A JA Lunevicius Raimundas R Magdy Abd El Razek Muhammed M Majeed Azeem A Makki Alaa A Male Shilpa S Malik Ahmad Azam AA Mansournia Mohammad Ali MA Martini Santi S Masoumi Seyedeh Zahra SZ Mathur Prashant P McKee Martin M Mehrotra Ravi R Mendoza Walter W Menezes Ritesh G RG Mengesha Endalkachew Worku EW Mesregah Mohamed Kamal MK Mestrovic Tomislav T Miao Jonasson Junmei J Miazgowski Bartosz B Miazgowski Tomasz T Michalek Irmina Maria IM Miller Ted R TR Mirzaei Hamed H Mirzaei Hamid Reza HR Misra Sanjeev S Mithra Prasanna P Moghadaszadeh Masoud M Mohammad Karzan Abdulmuhsin KA Mohammad Yousef Y Mohammadi Mokhtar M Mohammadi Seyyede Momeneh SM Mohammadian-Hafshejani Abdollah A Mohammed Shafiu S Moka Nagabhishek N Mokdad Ali H AH Molokhia Mariam M Monasta Lorenzo L Moni Mohammad Ali MA Moosavi Mohammad Amin MA Moradi Yousef Y Moraga Paula P Morgado-da-Costa Joana J Morrison Shane Douglas SD Mosapour Abbas A Mubarik Sumaira S Mwanri Lillian L Nagarajan Ahamarshan Jayaraman AJ Nagaraju Shankar Prasad SP Nagata Chie C Naimzada Mukhammad David MD Nangia Vinay V Naqvi Atta Abbas AA Narasimha Swamy Sreenivas S Ndejjo Rawlance R Nduaguba Sabina O SO Negoi Ionut I Negru Serban Mircea SM Neupane Kandel Sandhya S Nguyen Cuong Tat CT Nguyen Huong Lan Thi HLT Niazi Robina Khan RK Nnaji Chukwudi A CA Noor Nurulamin M NM Nuñez-Samudio Virginia V Nzoputam Chimezie Igwegbe CI Oancea Bogdan B Ochir Chimedsuren C Odukoya Oluwakemi Ololade OO Ogbo Felix Akpojene FA Olagunju Andrew T AT Olakunde Babayemi Oluwaseun BO Omar Emad E Omar Bali Ahmed A Omonisi Abidemi E Emmanuel AEE Ong Sokking S Onwujekwe Obinna E OE Orru Hans H Ortega-Altamirano Doris V DV Otstavnov Nikita N Otstavnov Stanislav S SS Owolabi Mayowa O MO P A Mahesh M Padubidri Jagadish Rao JR Pakshir Keyvan K Pana Adrian A Panagiotakos Demosthenes D Panda-Jonas Songhomitra S Pardhan Shahina S Park Eun-Cheol EC Park Eun-Kee EK Pashazadeh Kan Fatemeh F Patel Harsh K HK Patel Jenil R JR Pati Siddhartha S Pattanshetty Sanjay M SM Paudel Uttam U Pereira David M DM Pereira Renato B RB Perianayagam Arokiasamy A Pillay Julian David JD Pirouzpanah Saeed S Pishgar Farhad F Podder Indrashis I Postma Maarten J MJ Pourjafar Hadi H Prashant Akila A Preotescu Liliana L Rabiee Mohammad M Rabiee Navid N Radfar Amir A Radhakrishnan Raghu Anekal RA Radhakrishnan Venkatraman V Rafiee Ata A Rahim Fakher F Rahimzadeh Shadi S Rahman Mosiur M Rahman Muhammad Aziz MA Rahmani Amir Masoud AM Rajai Nazanin N Rajesh Aashish A Rakovac Ivo I Ram Pradhum P Ramezanzadeh Kiana K Ranabhat Kamal K Ranasinghe Priyanga P Rao Chythra R CR Rao Sowmya J SJ Rawassizadeh Reza R Razeghinia Mohammad Sadegh MS Renzaho Andre M N AMN Rezaei Negar N Rezaei Nima N Rezapour Aziz A Roberts Thomas J TJ Rodriguez Jefferson Antonio Buendia JAB Rohloff Peter P Romoli Michele M Ronfani Luca L Roshandel Gholamreza G Rwegerera Godfrey M GM S Manjula M Sabour Siamak S Saddik Basema B Saeed Umar U Sahebkar Amirhossein A Sahoo Harihar H Salehi Sana S Salem Marwa Rashad MR Salimzadeh Hamideh H Samaei Mehrnoosh M Samy Abdallah M AM Sanabria Juan J Sankararaman Senthilkumar S Santric-Milicevic Milena M MM Sardiwalla Yaeesh Y Sarveazad Arash A Sathian Brijesh B Sawhney Monika M Saylan Mete M Schneider Ione Jayce Ceola IJC Sekerija Mario M Seylani Allen A Shafaat Omid O Shaghaghi Zahra Z Shaikh Masood Ali MA Shamsoddin Erfan E Shannawaz Mohammed M Sharma Rajesh R Sheikh Aziz A Sheikhbahaei Sara S Shetty Adithi A Shetty Jeevan K JK Shetty Pavanchand H PH Shibuya Kenji K Shirkoohi Reza R Shivakumar K M KM Shivarov Velizar V Siabani Soraya S Siddappa Malleshappa Sudeep K SK Silva Diego Augusto Santos DAS Singh Jasvinder A JA Sintayehu Yitagesu Y Skryabin Valentin Yurievich VY Skryabina Anna Aleksandrovna AA Soeberg Matthew J MJ Sofi-Mahmudi Ahmad A Sotoudeh Houman H Steiropoulos Paschalis P Straif Kurt K Subedi Ranjeeta R Sufiyan Mu'awiyyah Babale MB Sultan Iyad I Sultana Saima S Sur Daniel D Szerencsés Viktória V Szócska Miklós M Tabarés-Seisdedos Rafael R Tabuchi Takahiro T Tadbiri Hooman H Taherkhani Amir A Takahashi Ken K Talaat Iman M IM Tan Ker-Kan KK Tat Vivian Y VY Tedla Bemnet Amare A BAA Tefera Yonas Getaye YG Tehrani-Banihashemi Arash A Temsah Mohamad-Hani MH Tesfay Fisaha Haile FH Tessema Gizachew Assefa GA Thapar Rekha R Thavamani Aravind A Thoguluva Chandrasekar Viveksandeep V Thomas Nihal N Tohidinik Hamid Reza HR Touvier Mathilde M Tovani-Palone Marcos Roberto MR Traini Eugenio E Tran Bach Xuan BX Tran Khanh Bao KB Tran Mai Thi Ngoc MTN Tripathy Jaya Prasad JP Tusa Biruk Shalmeno BS Ullah Irfan I Ullah Saif S Umapathi Krishna Kishore KK Unnikrishnan Bhaskaran B Upadhyay Era E Vacante Marco M Vaezi Maryam M Valadan Tahbaz Sahel S Velazquez Diana Zuleika DZ Veroux Massimiliano M Violante Francesco S FS Vlassov Vasily V Vo Bay B Volovici Victor V Vu Giang Thu GT Waheed Yasir Y Wamai Richard G RG Ward Paul P Wen Yi Feng YF Westerman Ronny R Winkler Andrea Sylvia AS Yadav Lalit L Yahyazadeh Jabbari Seyed Hossein SH Yang Lin L Yaya Sanni S Yazie Taklo Simeneh Yazie TSY Yeshaw Yigizie Y Yonemoto Naohiro N Younis Mustafa Z MZ Yousefi Zabihollah Z Yu Chuanhua C Yuce Deniz D Yunusa Ismaeel I Zadnik Vesna V Zare Fariba F Zastrozhin Mikhail Sergeevich MS Zastrozhina Anasthasia A Zhang Jianrong J Zhong Chenwen C Zhou Linghui L Zhu Cong C Ziapour Arash A Zimmermann Ivan R IR Fitzmaurice Christina C Murray Christopher J L CJL Force Lisa M LM

JAMA oncology 20220301 3

<h4>Importance</h4>The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden.<h4>Objective</h4>To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic Index (SDI) quintiles from 2010 to 2019.<h4>Evidence review</h4>The GBD 2019 estimation methods were used to describe cancer incidence, mo ...[more]

PMID: 34967848

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Dataset Information

Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019.

Importance

Objective

Evidence review

Findings

Conclusions and relevance

Publications

Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019.

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