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Protocol for a machine learning algorithm predicting depressive disorders using the T1w/T2w ratio.


ABSTRACT: The T1w/T2w ratio is a novel magnetic resonance imaging (MRI) measure that is thought to be sensitive to cortical myelin. Using this novel measure requires developing novel pipelines for the data quality assurance, data analysis, and validation of the findings in order to apply the T1w/T2w ratio for classification of disorders associated with the changes in the myelin levels. In this article, we provide a detailed description of such a pipeline as well as the reference to the scripts used in our recent report that applied the T1w/T2w ratio and machine learning to classify individuals with depressive disorders from healthy controls.

SUBMITTER: Baranger DAA 

PROVIDER: S-EPMC8720909 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Protocol for a machine learning algorithm predicting depressive disorders using the T1w/T2w ratio.

Baranger David A A DAA   Halchenko Yaroslav O YO   Satz Skye S   Ragozzino Rachel R   Iyengar Satish S   Swartz Holly A HA   Manelis Anna A  

MethodsX 20211202


The T1w/T2w ratio is a novel magnetic resonance imaging (MRI) measure that is thought to be sensitive to cortical myelin. Using this novel measure requires developing novel pipelines for the data quality assurance, data analysis, and validation of the findings in order to apply the T1w/T2w ratio for classification of disorders associated with the changes in the myelin levels. In this article, we provide a detailed description of such a pipeline as well as the reference to the scripts used in our  ...[more]

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