PD-1 and PD-L1 Expression in Indian Women with Breast Cancer.

ABSTRACT:

Objective

The interaction between programmed cell death protein 1 (PD-1) on activated T-lymphocytes and programmed death-ligand 1 (PD-L1) on tumor cells or antigen-presenting cells sends immunosuppressive signals leading to the escape of tumor cells from the host anti-tumor immune response. Inhibiting this interaction with antibodies against PD-1 or PD-L1 is emerging as a valuable therapeutic strategy. However, tissue distribution patterns for PD-L1 and PD-1 in breast cancer patients from India are not reported, yet many clinical trials are underway. In this study the expression of PD-1 and PD-L1 in breast cancer patient samples from India was characterized.

Materials and methods

The study included 392 cases of operated breast cancer (2012-2017) from a tertiary cancer care c

SUBMITTER: Bharadwa KR 

PROVIDER: S-EPMC8734527 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature