Hepatitis C virus core mutations reduce the sensitivity of a fluorescence enzyme immunoassay.
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ABSTRACT:
SUBMITTER: Tokita H
PROVIDER: S-EPMC87404 | biostudies-literature | 2000 Sep
REPOSITORIES: biostudies-literature
Publications
Hepatitis C virus core mutations reduce the sensitivity of a fluorescence enzyme immunoassay.
Tokita H H Kaufmann G R GR Matsubayashi M M Okuda I I Tanaka T T Harada H H Mukaide M M Suzuki K K Cooper D A DA
Journal of clinical microbiology 20000901 9
Four of 107 samples obtained from hepatitis C virus (HCV) carriers showed lower HCV core antigen levels in a fluorescence enzyme immunoassay (FEIA) than expected from corresponding HCV RNA levels. Nucleotide sequencing revealed a mutation in the HCV core region (Thr49Pro) that appears to have reduced the FEIA sensitivity. ...[more]
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