Ontology highlight
ABSTRACT:
SUBMITTER: Focosi D
PROVIDER: S-EPMC8744556 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Focosi Daniele D Maggi Fabrizio F Franchini Massimo M McConnell Scott S Casadevall Arturo A
International journal of molecular sciences 20211221 1
The accelerated SARS-CoV-2 evolution under selective pressure by massive deployment of neutralizing antibody-based therapeutics is a concern with potentially severe implications for public health. We review here reports of documented immune escape after treatment with monoclonal antibodies and COVID-19-convalescent plasma (CCP). While the former is mainly associated with specific single amino acid mutations at residues within the receptor-binding domain (e.g., E484K/Q, Q493R, and S494P), a few c ...[more]