Overview of the Development and Use of Akt Inhibitors in Prostate Cancer.
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ABSTRACT:
SUBMITTER: Gasmi A
PROVIDER: S-EPMC8745410 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Publications
Overview of the Development and Use of Akt Inhibitors in Prostate Cancer.
Gasmi Anis A Roubaud Guilhem G Dariane Charles C Barret Eric E Beauval Jean-Baptiste JB Brureau Laurent L Créhange Gilles G Fiard Gaëlle G Fromont Gaëlle G Gauthé Mathieu M Ruffion Alain A Renard-Penna Raphaële R Sargos Paul P Rouprêt Morgan M Ploussard Guillaume G Mathieu Romain R
Journal of clinical medicine 20211229 1
Deregulation of the PI3K-Akt-mTOR pathway plays a critical role in the development and progression of many cancers. In prostate cancer, evidence suggests that it is mainly driven by PTEN loss of function. For many years, the development of selective Akt inhibitors has been challenging. In recent phase II and III clinical trials, Ipatasertib and Capivasertib associated with androgen deprivation therapies showed promising outcomes in patients with metastatic castration-resistant prostate cancer an ...[more]
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