Resonator nanophotonic standing-wave array trap for single-molecule manipulation and measurement.

ABSTRACT: Nanophotonic tweezers represent emerging platforms with significant potential for parallel manipulation and measurements of single biological molecules on-chip. However, trapping force generation represents a substantial obstacle for their broader utility. Here, we present a resonator nanophotonic standing-wave array trap (resonator-nSWAT) that demonstrates significant force enhancement. This platform integrates a critically-coupled resonator design to the nSWAT and incorporates a novel trap reset scheme. The nSWAT can now perform standard single-molecule experiments, including stretching DNA molecules to measure their force-extension relations, unzipping DNA molecules, and disrupting and mapping protein-DNA interactions. These experiments have realized trapping forces on the order of 20 p

SUBMITTER: Ye F 

PROVIDER: S-EPMC8748738 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature