Unknown

Dataset Information

0

Interleukin-8 in Melanoma Pathogenesis, Prognosis and Therapy-An Integrated View into Other Neoplasms and Chemokine Networks.


ABSTRACT: Cutaneous melanoma accounts for only about 7% of skin cancers but is causing almost 90% of deaths. Melanoma cells have a distinct repertoire of mutations from other cancers, a high plasticity and degree of mimicry toward vascular phenotype, stemness markers, versatility in evading and suppress host immune control. They exert a significant influence on immune, endothelial and various stromal cells which form tumor microenvironment. The metastatic stage, the leading cause of mortality in this neoplasm, is the outcome of a complex, still poorly understood, cross-talk between tumor and other cell phenotypes. There is accumulating evidence that Interleukin-8 (IL-8) is emblematic for advanced melanomas. This work aimed to present an updated status of IL-8 in melanoma tumor cellular complexity, through a comprehensive analysis including data from other chemokines and neoplasms. The multiple processes and mechanisms surveyed here demonstrate that IL-8 operates following orchestrated programs within signaling webs in melanoma, stromal and vascular cells. Importantly, the yet unknown molecularity regulating IL-8 impact on cells of the immune system could be exploited to overturn tumor fate. The molecular and cellular targets of IL-8 should be brought into the attention of even more intense scientific exploration and valorization in the therapeutical management of melanoma.

SUBMITTER: Filimon A 

PROVIDER: S-EPMC8750532 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC9947295 | biostudies-literature
| S-EPMC3335030 | biostudies-literature
| S-EPMC4893887 | biostudies-literature
| S-EPMC6409191 | biostudies-literature
| S-EPMC4369822 | biostudies-literature
| S-EPMC8246678 | biostudies-literature
| S-EPMC7773644 | biostudies-literature
| S-EPMC8431576 | biostudies-literature
| S-EPMC8486282 | biostudies-literature
| S-EPMC8779845 | biostudies-literature