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Harnessing Antitumor CD4+ T Cells for Cancer Immunotherapy.


ABSTRACT: Over the past decades, CD4+ T cells have been considered as a supporting actor in the fields of cancer immunotherapy. Until recently, accumulating evidence has demonstrated the critical role of CD4+ T cells during antitumor immunity. CD4+ T cells can either suppress or promote the antitumor cytotoxic CD8+ T cell responses, either in secondary lymphoid organs or in the tumor. In this review, we provide an overview of the multifaceted role of different CD4+ T cell subsets in cancer immune response and their contribution during cancer therapies. Specifically, we focus on the latest progress regarding the impact of CD4+ T cell modulation on immunotherapies and other cancer therapies and discuss the prospect for harnessing CD4+ T cells to control tumor progression and prevent recurrence in patients.

SUBMITTER: Ben Khelil M 

PROVIDER: S-EPMC8750687 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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Harnessing Antitumor CD4<sup>+</sup> T Cells for Cancer Immunotherapy.

Ben Khelil Myriam M   Godet Yann Y   Abdeljaoued Syrine S   Borg Christophe C   Adotévi Olivier O   Loyon Romain R  

Cancers 20220105 1


Over the past decades, CD4<sup>+</sup> T cells have been considered as a supporting actor in the fields of cancer immunotherapy. Until recently, accumulating evidence has demonstrated the critical role of CD4<sup>+</sup> T cells during antitumor immunity. CD4<sup>+</sup> T cells can either suppress or promote the antitumor cytotoxic CD8<sup>+</sup> T cell responses, either in secondary lymphoid organs or in the tumor. In this review, we provide an overview of the multifaceted role of different C  ...[more]

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