Unknown

Dataset Information

0

The role of CD36 in cardiovascular disease.


ABSTRACT: CD36, also known as the scavenger receptor B2, is a multifunctional receptor widely expressed in various organs. CD36 plays a crucial role in the uptake of long-chain fatty acids, the main metabolic substrate in myocardial tissue. The maturation and transportation of CD36 is regulated by post-translational modifications, including phosphorylation, ubiquitination, glycosylation, and palmitoylation. CD36 is decreased in pathological cardiac hypertrophy caused by ischaemia-reperfusion and pressure overload, and increased in diabetic cardiomyopathy and atherosclerosis. Deficiency of CD36 alleviates diabetic cardiomyopathy and atherosclerosis, while overexpression of CD36 eliminates ischaemia-reperfusion damage, together suggesting that CD36 is closely associated with the progression of cardiovascular diseases and may be a new therapeutic target. This review summarizes the regulation and post-translational modifications of CD36 and evaluates its role in cardiovascular diseases and its potential as a therapeutic target.

SUBMITTER: Shu H 

PROVIDER: S-EPMC8752351 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC6684090 | biostudies-literature
| S-EPMC5536028 | biostudies-literature
| S-EPMC6496801 | biostudies-literature
| S-EPMC6021027 | biostudies-literature
| S-EPMC7586427 | biostudies-literature
| S-EPMC3258388 | biostudies-literature
| S-EPMC7595665 | biostudies-literature
| S-EPMC7602155 | biostudies-literature
| S-EPMC5124501 | biostudies-literature
| S-EPMC4361670 | biostudies-literature