Cancer biology and molecular genetics of A3 adenosine receptor.
Ontology highlight
ABSTRACT:
SUBMITTER: Mazziotta C
PROVIDER: S-EPMC8755539 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Publications
Cancer biology and molecular genetics of A<sub>3</sub> adenosine receptor.
Mazziotta Chiara C Rotondo John Charles JC Lanzillotti Carmen C Campione Giulia G Martini Fernanda F Tognon Mauro M
Oncogene 20211108 3
A<sub>3</sub> adenosine receptor (A<sub>3</sub>AR) is a cell membrane protein, which has been found to be overexpressed in a large number of cancer types. This receptor plays an important role in cancer by interacting with adenosine. Specifically, A<sub>3</sub>AR has a dual nature in different pathophysiological conditions, as it is expressed according to tissue type and stimulated by an adenosine dose-dependent manner. A<sub>3</sub>AR activation leads to tumor growth, cell proliferation and sur ...[more]
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