A Quantitative Framework to Study Potential Benefits and Harms of Multi-Cancer Early Detection Testing.

ABSTRACT:

Background

Multi-cancer tests offer screening for multiple cancers with one blood draw, but the potential population impact is poorly understood.

Methods

We formulate mathematical expressions for expected numbers of: (i) individuals exposed to unnecessary confirmation tests (EUC), (ii) cancers detected (CD), and (iii) lives saved (LS) given test performance, disease incidence and mortality, and mortality reduction. We add colorectal, liver, lung, ovary, and pancreatic cancer to a test for breast cancer, approximating prevalence at ages 50, 60, or 70 using incidence over the next 5 years and mortality using corresponding probabilities of cancer death over 15 years in the Surveillance, Epidemiology, and End Results registry.

Results

EUC is overwhelmingly determined by s

SUBMITTER: Jiao B 

PROVIDER: S-EPMC8755582 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature