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ABSTRACT: Objectives
Electrocardiographic (ECG) changes have been associated with COVID-19 severity. However, the progression of ECG findings in COVID-19 patients has not been studied. The purpose of this study was to describe ECG features at different stages of COVID-19 cardiovascular (CV) events and to examine the effects of specific ECG parameters and cardiac-related biomarkers on clinical outcomes in COVID-19. Design
Retrospective, cohort study Setting
Major tertiary care medical centers and community hospitals in Louisville, KY, USA Participants
124 COVID-19 patients who suffered cardiovascular events during hospitalization. Interventions
None Measurements and Main Results
12 lead ECG parameters, biomarkers of cardiac injuries, and clinical outcomes were analyzed with Spearman's correlation coefficients and Kruskal–Wallis one-way ANOVA. Atrial fibrillation/atrial flutter was more frequent in ECG obtained at the time of CV event when compared to admission ECG (9.5% vs. 26.9%; P = .007). Sinus tachycardia was higher in the last available hospital ECG than CV event ECG (37.5% vs. 20.4%; P = .031). Admission ECG QTc was significantly associated with admission troponin levels (R = 0.52, P < .001). The last available hospital ECG showed non-survivors had longer QRS duration than survivors (114.6 vs. 91.2 ms; P = .026), and higher heart rate was associated with longer ICU length of stay (Spearman ρ = 0.339, P = .032). Conclusions
In hospitalized COVID-19 patients who suffered cardiovascular events, ECGs at various stages of COVID-19 hospitalization showed significantly different features with dissimilar clinical outcome correlations.
SUBMITTER: Nathala P
PROVIDER: S-EPMC8757653 | biostudies-literature |
REPOSITORIES: biostudies-literature