Browse
Submit Data
Databases
API
Help

Dataset Information

8 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Sunscreens with the New MCE Filter Cover the Whole UV Spectrum: Improved UVA1 Photoprotection In Vitro and in a Randomized Controlled Trial.

ABSTRACT:

Background

UVA1 rays (340-400 nm) contribute to carcinogenesis, immunosuppression, hyperpigmentation, and aging. Current sunscreen formulas lack sufficient absorption in the 370-400 nm wavelengths range. Recently, a new UVA1 filter, Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate (MCE) exhibiting a peak of absorption at 385 nm, was approved by the Scientific Committee on Consumer Safety for use in sunscreen products. These studies evaluated, in a three-dimensional skin model and in vivo, the protection afforded by state-of-the-art sunscreen formulations enriched with MCE.

Trial design

This study is a monocentric, double-blinded, randomized, and comparative trial. This study is registered at ClinicalTrials.gov with the identification number NCT04865094.

Methods

The efficacy of sunscreens with MCE was compared with that of reference formulas. In a three-dimensional skin model, histology, protein, and gene expression were analyzed. In the clinical trial, pigmentation was analyzed in 19 volunteers using colorimetric measurements and visual scoring.

Results

MCE addition in reference formulas enlarged the profile of absorption up to 400 nm; reduced UVA1-induced dermal and epidermal alterations at cellular, biochemical, and molecular levels; and decreased UVA1-induced pigmentation.

Conclusions

Addition of MCE absorber in sunscreen formulations leads to full coverage of UV spectrum and improved UVA1 photoprotection. The data support benefits in the long term on sun-induced consequences, especially those related to public health care issues.

SUBMITTER: Marionnet C

PROVIDER: S-EPMC8762479 | biostudies-literature |

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Similar Datasets

Microencapsulated UV filter@ZIF-8 based sunscreens for broad spectrum UV protection.

Project description:Sunscreens play a vital role in protecting human skin from photodamage upon UV exposure, but their effectiveness is limited by degradation and phototoxicity. Photoactivation of UV filters in sunscreen can generate reactive oxygen species, with accompanying cytotoxicity. Herein, we report stable, safe, fluorescent, and long-lasting sunscreens produced by microencapsulation of organic UV filters octylmethoxycinnamate (OMC) and butyl-methoxydibenzoylmethane (BMDM), alone and together, into a microporous zeolitic imidazole framework (ZIF-8). The visibly transparent OMC + BMDM@ZIF-8 sunscreens displayed complete broad-spectrum photoprotection against UV light even after 24 hours. Photostability testing of the sunscreens demonstrated the photo-protective nature of microporous ZIF-8 for stabilizing these UV filters. The sun protection factor (SPF) values for lotions containing 10% (w/w) OMC@ZIF-8, BMDM@ZIF-8 and OMC + BMDM@ZIF-8 sunscreens decreased from 29.8 to 26.0, 32.5 to 26.4, and 62.1 to 53.0, respectively, upon 24 hours of intense UV exposure. No release of the UV filters from the encapsulated formulations was observed. The ZIF-8 particles are too large to be transported across the stratum corneum. Thus, our findings suggest that zeolitic framework-encapsulated sunscreens could provide prolonged UV-protection efficacy and ultra-high SPF with reduced potential for degradation, phototoxicity, and transport across the skin.

| S-EPMC9056713 | biostudies-literature

Wavepacket insights into the photoprotection mechanism of the UV filter methyl anthranilate.

Project description:Meradimate is a broad-spectrum ultraviolet absorber used as a chemical filter in commercial sunscreens. Herein, we explore the ultrafast photodynamics occurring in methyl anthranilate (precursor to Meradimate) immediately after photoexcitation with ultraviolet radiation to understand the mechanisms underpinning Meradimate photoprotection. Using time-resolved photoelectron spectroscopy, signal from the first singlet excited state of methyl anthranilate shows an oscillatory behavior, i.e., quantum beats. Our studies reveal a dependence of the observed beating frequencies on photoexcitation wavelength and photoelectron kinetic energy, unveiling the different Franck-Condon overlaps between the vibrational levels of the ground electronic, first electronic excited, and ground cationic states of methyl anthranilate. By evaluating the behavior of these beats with increasing photon energy, we find evidence for intramolecular vibrational energy redistribution on the first electronic excited state. Such energy redistribution hinders efficient relaxation of the electronic excited state, making methyl anthranilate a poor choice for an efficient, efficacious sunscreen chemical filter.

| S-EPMC6281654 | biostudies-literature

Zinc-metal-organic frameworks with tunable UV diffuse-reflectance as sunscreens.

Project description:BackgroundUV exposure continues to induce many health issues, though commercial sunscreens are available. Novel UV filters with high safety and efficacy are urgently needed. Metal-organic frameworks (MOFs) could be a suitable platform for UV filter development, due to their tunable optical, electrical, and photoelectric properties by precise controlled synthesis.ResultsHerein, four zinc-based MOFs with various bandgap energies were chose to investigate their optical behaviors and evaluate their possibility as sunscreens. Zeolitic imidazolate framework-8 (ZIF-8) was found to possess the highest and widest UV reflectance, thereby protecting against sunburn and DNA damage on mouse skin and even achieving a comparable or higher anti-UV efficacy relative to the commercially available UV filters, TiO2 or ZnO, on pig skin, a model that correlates well with human skin. Also, ZIF-8 exerted appealing characteristics for topical skin use with low radical production, low skin penetration, low toxicity, high transparency, and high stability.ConclusionThese results confirmed ZIF-8 could potentially be a safe and effective sunscreen surrogate for human, and MOFs could be a novel source to develop more effective and safe UV filters.

| S-EPMC8858458 | biostudies-literature

Transcriptional repression by AtMYB4 controls production of UV-protecting sunscreens in Arabidopsis.

Project description:An Arabidopsis thaliana line that is mutant for the R2R3 MYB gene, AtMYB4, shows enhanced levels of sinapate esters in its leaves. The mutant line is more tolerant of UV-B irradiation than wild type. The increase in sinapate ester accumulation in the mutant is associated with an enhanced expression of the gene encoding cinnamate 4-hydroxylase, which appears to be the principal target of AtMYB4 and an effective rate limiting step in the synthesis of sinapate ester sunscreens. AtMYB4 expression is downregulated by exposure to UV-B light, indicating that derepression is an important mechanism for acclimation to UV-B in A.thaliana. The response of target genes to AtMYB4 repression is dose dependent, a feature that operates under physiological conditions to reinforce the silencing effect of AtMYB4 at high activity. AtMYB4 works as a repressor of target gene expression and includes a repression domain. It belongs to a novel group of plant R2R3 MYB proteins involved in transcriptional silencing. The balance between MYB activators and repressors on common target promoters may provide extra flexibility in transcriptional control.

| S-EPMC305818 | biostudies-literature

Novel wideband MIMO antennas that can cover the whole LTE spectrum in handsets and portable computers.

Project description:A dual resonant antenna configuration is developed for multistandard multifunction mobile handsets and portable computers. Only two wideband resonant antennas can cover most of the LTE spectrums in portable communication equipment. The bandwidth that can be covered by each antenna exceeds 70% without using any matching or tuning circuits, with efficiencies that reach 80%. Thus, a dual configuration of them is capable of covering up to 39 LTE (4G) bands besides the existing 2G and 3G bands. 2×2 MIMO configurations have been also developed for the two wideband antennas with a maximum isolation and a minimum correlation coefficient between the primary and the diversity antennas.

| S-EPMC3914584 | biostudies-other

UV Photoprotection and Long-lasting Pigmentation from UVA and/or UVB

2014-12-12 | GSE56754 | GEO

Antioxidant and UV-radiation absorption activity of aaptamine derivatives - potential application for natural organic sunscreens.

Project description:Antioxidant and UV absorption activities of three aaptamine derivatives including piperidine[3,2-b]demethyl(oxy)aaptamine (C1), 9-amino-2-ethoxy-8-methoxy-3H-benzo[de][1,6]naphthyridine-3-one (C2), and 2-(sec-butyl)-7,8-dimethoxybenzo[de]imidazo[4,5,1-ij][1,6]-naphthyridin-10(9H)-one (C3) were theoretically studied by density functional theory (DFT). Direct antioxidant activities of C1-C3 were firstly evaluated via their intrinsic thermochemical properties and the radical scavenging activity of the potential antioxidants with the HOO˙/HO˙ radicals via four mechanisms, including: hydrogen atom transfer (HAT), single electron transfer (SET), proton loss (PL) and radical adduct formation (RAF). Kinetic calculation reveals that HOO˙ scavenging in water occurs via HAT mechanism with C1 (k app, 7.13 × 106 M-1 s-1) while RAF is more dominant with C2 (k app, 1.40 × 105 M-1 s-1) and C3 (k app, 2.90 × 105 M-1 s-1). Antioxidant activity of aaptamine derivatives can be classified as C1 > C3 > C2. Indirect antioxidant properties based on Cu(i) and Cu(ii) ions chelating activity were also investigated in aqueous phase. All three studied compounds show spontaneous and favorable Cu(i) ion chelating activity with ΔG 0 being -15.4, -13.7, and -15.7 kcal mol-1, whereas ΔG 0 for Cu(ii) chelation are -10.4, -10.8, and -2.2 kcal mol-1 for C1, C2 and C3, respectively. In addition, all compounds show UVA and UVB absorption; in which the excitations are determined mostly as π-π* transition. Overall, the results suggest the potential applications of the aaptamines in pharmaceutics and cosmetics, i.e. as a sunscreen and antioxidant ingredient.

| S-EPMC9034140 | biostudies-literature

Preparation and Application of Light-Colored Lignin Nanoparticles for Broad-Spectrum Sunscreens.

Project description:Recently, natural sun blockers have been drawing considerable attention because synthetic UV filters could have adverse effects not only on humans but also on the environment. Even though lignin, the second most abundant renewable resource on earth, is a natural UV-absorbing polymer, its unfavorable dark color hampers its applications in sunscreens. In this work, we obtained light-colored lignin (CEL) from rice husks through cellulolytic enzyme treatment and subsequent solvent extraction under mild conditions and compared CEL to technical lignin from rice husks using the International Commission on Illumination L*a*b* (CIELAB) color space. Spherical nanoparticles of CEL (CEL-NP) were also prepared using a solvent shifting method and evaluated for broad-spectrum sunscreens. A moisturizing cream blended with CEL-NP exhibited higher sun protection factor (SPF) and UVA PF (protection factor) values than that with CEL. In addition, CEL-NP had synergistic effects when blended with an organic UV-filter sunscreen: CEL-NP enhanced the SPF and UVA PF values of the sunscreen greatly. However, there was no synergistic effect between CEL-NP and inorganic sunscreens. We expect nanoparticles of light-colored lignin to find high-value-added applications as a natural UV-blocking additive in sunscreens and cosmetics.

| S-EPMC7183278 | biostudies-literature

UV Photoprotection and Long-lasting Pigmentation from UVA and/or UVB

Project description:To test whether there is a photoprotective benefit after different types of suberythemal repetitive UV, a 1.5 MED challenge dose was applied 1 week after the initial 2 weeks of repetitive irradiation. To determine what different mechanisms and/or factors might be involved in physiological pigmentary responses of the skin to different types of UV, we used whole human genome microarrays and immunohistochemical analyses to characterize human skin in situ to examine how melanocyte-specific proteins and paracrine melanogenic factors are regulated by repetitive exposure to suberythemal doses of different types of UV (UVA and/or UVB). Seven volunteers with skin type II-III were irradiated with UVA, UVB or UVA+UVB radiation for 2 weeks (5 times per week, 10 times total) after preliminary determination of their MEDs. A UVA+UVB challenge dose of 1.5X the MED was applied 1 week later. Biopsies were taken before the challenge dose, immediately after the challenge dose, 4 days after the challenge, and 15 weeks after the challenge.

2014-12-12 | E-GEOD-56754 | biostudies-arrayexpress

Improved Correlation Filter Tracking with Enhanced Features and Adaptive Kalman Filter.

Project description:In the field of visual tracking, discriminative correlation filter (DCF)-based trackers have made remarkable achievements with their high computational efficiency. The crucial challenge that still remains is how to construct qualified samples without boundary effects and redetect occluded targets. In this paper a feature-enhanced discriminative correlation filter (FEDCF) tracker is proposed, which utilizes the color statistical model to strengthen the texture features (like the histograms of oriented gradient of HOG) and uses the spatial-prior function to suppress the boundary effects. Then, improved correlation filters using the enhanced features are built, the optimal functions of which can be effectively solved by Gauss-Seidel iteration. In addition, the average peak-response difference (APRD) is proposed to reflect the degree of target-occlusion according to the target response, and an adaptive Kalman filter is established to support the target redetection. The proposed tracker achieved a success plot performance of 67.8% with 5.1 fps on the standard datasets OTB2013.

| S-EPMC6479297 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data