Unknown

Dataset Information

0

Neuropilin-1, a myeloid cell-specific protein, is an inhibitor of HIV-1 infectivity.


ABSTRACT: Myeloid lineage cells such as macrophages and dendritic cells (DCs), targeted by HIV-1, are important vehicles for virus dissemination through the body as well as viral reservoirs. Compared to activated lymphocytes, myeloid cells are collectively more resistant to HIV-1 infection. Here we report that NRP-1, encoding transmembrane protein neuropilin-1, is highly expressed in macrophages and DCs but not CD4+ T cells, serving as an anti-HIV factor to inhibit the infectivity of HIV-1 progeny virions. Silencing NRP-1 enhanced the transmission of HIV-1 in macrophages and DCs significantly and increased the infectivity of the virions produced by these cells. We further demonstrated that NRP-1 was packaged into the progeny virions to inhibit their ability to attach to target cells, thus reducing the infectivity of the virions. These data indicate that NRP-1 is a newly identified antiviral protein highly produced in both macrophages and DCs that inhibit HIV-1 infectivity; thus, NRP-1 may be a novel therapeutic strategy for the treatment of HIV-1 infection.

SUBMITTER: Wang S 

PROVIDER: S-EPMC8764665 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC7857391 | biostudies-literature
| S-EPMC4347252 | biostudies-literature
| S-EPMC4369413 | biostudies-literature
| S-EPMC6607583 | biostudies-literature
| S-EPMC3228482 | biostudies-literature
| S-EPMC3178557 | biostudies-literature
| S-EPMC10470580 | biostudies-literature
| S-EPMC4957839 | biostudies-other
| S-EPMC6289579 | biostudies-literature
| S-EPMC3595993 | biostudies-literature