Monoclonal Antibody Treatment of Breakthrough COVID-19 in Fully Vaccinated Individuals with High-Risk Comorbidities.
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ABSTRACT: Background
Breakthrough coronavirus disease 2019 (COVID-19) may occur in fully vaccinated persons.Methods
We assessed the clinical outcomes of breakthrough COVID-19 in fully vaccinated individuals.Results
In this cohort of 1395 persons (mean age, 54.3 years; 60% female; median body mass index, 30.7) who developed breakthrough COVID- 19, there were 107 (7.7%) who required hospitalization by day 28. Hospitalization was significantly associated with the number of medical comorbidities. Antispike monoclonal antibody treatment was significantly associated with a lower risk of hospitalization (odds ratio, 0.227; 95% confidence interval, 0.128-0.403; P < .001). The number needed to treat (NNT) to prevent 1 hospitalization was 225 among the lowest risk patient group compared with NNT of 4 among those with highest numbers of medical comorbidity.Conclusions
Monoclonal antibody treatment is associated with reduced hospitalization in vaccinated high-risk persons with mild to moderate COVID-19.
SUBMITTER: Bierle DM
PROVIDER: S-EPMC8767864 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Publications
Monoclonal Antibody Treatment of Breakthrough COVID-19 in Fully Vaccinated Individuals with High-Risk Comorbidities.
Bierle Dennis M DM Ganesh Ravindra R Tulledge-Scheitel Sidna S Hanson Sara N SN Arndt Lori L LL Wilker Caroline G CG Razonable Raymund R RR
The Journal of infectious diseases 20220201 4
<h4>Background</h4>Breakthrough coronavirus disease 2019 (COVID-19) may occur in fully vaccinated persons.<h4>Methods</h4>We assessed the clinical outcomes of breakthrough COVID-19 in fully vaccinated individuals.<h4>Results</h4>In this cohort of 1395 persons (mean age, 54.3 years; 60% female; median body mass index, 30.7) who developed breakthrough COVID- 19, there were 107 (7.7%) who required hospitalization by day 28. Hospitalization was significantly associated with the number of medical com ...[more]
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