Dataset Information

SARS-CoV-2 viral dynamics of the first 1000 sequences from Vietnam and neighbouring ASEAN countries

ABSTRACT:

OSbjective

: The regional distribution and transmissibility of existing COVID-19 variants of concern (VOC) has led to concerns about increased transmission, given the ability of VOCs to evade immunity as breakthrough infections increase.

Methods

: SARS-CoV-2 genomes were sequenced (n=277) and analysed with all available genomes from Vietnam and ASEAN countries to understand the phylodynamics. The observed lineages were assigned using Pangolin nomenclature and spread patterns were investigated.

Results

: Between January 2020 and 08 November 2021, VOCs including alpha (B.1.1.7), beta (B.1.351), gamma (P.1), and delta (B.1.617.2), were observed in ASEAN countries. While alpha and delta were the major VOCs in nine ASEAN countries, delta is the predominant. Among ASEAN countries, alpha VOC was first reported by Singapore, beta VOC by Malaysia, gamma VOC by Philippines and delta VOC by Singapore. Of the first 1000 genomes analysed from Vietnam, alpha and delta are the most represented, with delta being the dominant VOC since May 2021. The delta variant was introduced in early January 2021 and forms a large cluster within the representative genomes.

Conclusion

: Spatial and temporal monitoring of SARS-CoV-2 variants is critical to understanding viral phylodynamics and will provide useful guidance to policy makers for infection prevention and control.

SUBMITTER: Hoan N

PROVIDER: S-EPMC8770528 | biostudies-literature |

REPOSITORIES: biostudies-literature

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