Unknown

Dataset Information

0

Marine Depsipeptide Nobilamide I Inhibits Cancer Cell Motility and Tumorigenicity via Suppressing Epithelial-Mesenchymal Transition and MMP2/9 Expression.

ABSTRACT: A cyclic depsipeptide, nobilamide I (1), along with the known peptide A-3302-B/TL-119 (2), was isolated from the saline cultivation of the marine-derived bacterium Saccharomonospora sp., strain CNQ-490. The planar structure of 1 was elucidated by interpretation of 1D and 2D NMR and MS spectroscopic data. The absolute configurations of the amino acids in 1 were assigned by using the C3 Marfey's analysis and comparing them with those of 2 based on their biosynthetic pathways. Nobilamide I (1) decreased cell motility by inhibiting epithelial-mesenchymal transition markers in A549 (lung cancer), AGS (gastric cancer), and Caco2 (colorectal cancer) cell lines. In addition, 1 modulated the expression of the matrix metalloproteinase (MMP) family (MMP2 and MMP9) in the three cell lines.

SUBMITTER: Le TC 

PROVIDER: S-EPMC8771697 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Marine Depsipeptide Nobilamide I Inhibits Cancer Cell Motility and Tumorigenicity via Suppressing Epithelial-Mesenchymal Transition and MMP2/9 Expression.

Le Tu Cam TC   Pulat Sultan S   Lee Jihye J   Kim Geum Jin GJ   Kim Haerin H   Lee Eun-Young EY   Hillman Prima F PF   Choi Hyukjae H   Yang Inho I   Oh Dong-Chan DC   Kim Hangun H   Nam Sang-Jip SJ   Fenical William W  

ACS omega 20220103 2

A cyclic depsipeptide, nobilamide I (<b>1</b>), along with the known peptide A-3302-B/TL-119 (<b>2</b>), was isolated from the saline cultivation of the marine-derived bacterium <i>Saccharomonospora</i> sp., strain CNQ-490. The planar structure of <b>1</b> was elucidated by interpretation of 1D and 2D NMR and MS spectroscopic data. The absolute configurations of the amino acids in <b>1</b> were assigned by using the C<sub>3</sub> Marfey's analysis and comparing them with those of <b>2</b> based  ...[more]

Similar Datasets

Unknown ERp29 inhibits tumorigenicity by suppressing epithelial mesenchymal transition in gastric cancer.
| S-EPMC5667996 | biostudies-literature
Unknown Downregulated expression of hepatoma-derived growth factor inhibits migration and invasion of prostate cancer cells by suppressing epithelial-mesenchymal transition and MMP2, MMP9.
| S-EPMC5754131 | biostudies-literature
Unknown SELENBP1 inhibits progression of colorectal cancer by suppressing epithelial-mesenchymal transition.
| S-EPMC9438969 | biostudies-literature
Unknown Lamp2 inhibits epithelial-mesenchymal transition by suppressing Snail expression in HCC.
| S-EPMC6084387 | biostudies-literature
Unknown ERα inhibits epithelial-mesenchymal transition by suppressing Bmi1 in breast cancer.
| S-EPMC4673297 | biostudies-literature
Unknown Atg7 inhibits Warburg effect by suppressing PKM2 phosphorylation resulting reduced epithelial-mesenchymal transition.
| S-EPMC6001680 | biostudies-literature
Unknown FRK inhibits breast cancer cell migration and invasion by suppressing epithelial-mesenchymal transition.
| S-EPMC5762571 | biostudies-literature
Unknown Ursolic acid inhibits glioblastoma through suppressing TGFβ-mediated epithelial-mesenchymal transition (EMT) and angiogenesis.
| S-EPMC10945258 | biostudies-literature
Unknown Grainyhead-like 2 inhibits the coactivator p300, suppressing tubulogenesis and the epithelial-mesenchymal transition.
| S-EPMC4966987 | biostudies-literature
Unknown TPM3 mediates epithelial-mesenchymal transition in esophageal cancer via MMP2/MMP9.
| S-EPMC8422148 | biostudies-literature