Ontology highlight
ABSTRACT:
SUBMITTER: Yuan Y
PROVIDER: S-EPMC8772707 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Yuan Yi Y Rosado-Lugo Jesus D JD Zhang Yongzheng Y Datta Pratik P Sun Yangsheng Y Cao Yanlu Y Banerjee Anamika A Parhi Ajit K AK
Antibiotics (Basel, Switzerland) 20211228 1
The ability to rescue the activity of antimicrobials that are no longer effective against bacterial pathogens such as <i>Pseudomonas aeruginosa</i> is an attractive strategy to combat antimicrobial drug resistance. Herein, novel efflux pump inhibitors (EPIs) demonstrating strong potentiation in combination with levofloxacin against wild-type <i>P. aeruginosa</i> ATCC 27853 are presented. A structure activity relationship of aryl substituted heterocyclic carboxamides containing a pentane diamine ...[more]