Ontology highlight
ABSTRACT:
SUBMITTER: Raabe FJ
PROVIDER: S-EPMC8773672 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Raabe Florian J FJ Stephan Marius M Waldeck Jan Benedikt JB Huber Verena V Demetriou Damianos D Kannaiyan Nirmal N Galinski Sabrina S Glaser Laura V LV Wehr Michael C MC Ziller Michael J MJ Schmitt Andrea A Falkai Peter P Rossner Moritz J MJ
Cells 20220111 2
Oligodendrocytes (OLs) are critical for myelination and are implicated in several brain disorders. Directed differentiation of human-induced OLs (iOLs) from pluripotent stem cells can be achieved by forced expression of different combinations of the transcription factors SOX10 (S), OLIG2 (O), and NKX6.2 (N). Here, we applied quantitative image analysis and single-cell transcriptomics to compare different transcription factor (TF) combinations for their efficacy towards robust OL lineage conversi ...[more]