Ontology highlight
ABSTRACT:
SUBMITTER: Yang F
PROVIDER: S-EPMC8774747 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Yang Fang F Gracia Gervasi Maria M Orta Gerardo G Tourzani Darya A DA De la Vega-Beltrán Jose Luis JL Ruthel Gordon G Darszon Alberto A Visconti Pablo E PE Wang P Jeremy PJ
Development (Cambridge, England) 20220114 2
The CatSper cation channel is essential for sperm capacitation and male fertility. The multi-subunit CatSper complexes form highly organized calcium signaling nanodomains on flagellar membranes. Here, we report identification of an uncharacterized protein, C2CD6, as a subunit of the mouse CatSper complex. C2CD6 contains a calcium-dependent, membrane-targeting C2 domain. C2CD6 associates with the CatSper calcium-selective, core-forming subunits. Deficiency of C2CD6 depletes the CatSper nanodomain ...[more]