Ontology highlight
ABSTRACT:
SUBMITTER: Zhao Y
PROVIDER: S-EPMC9205950 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Zhao Yanhe Y Wang Huafeng H Wiesehoefer Caroline C Shah Naman B NB Reetz Evan E Hwang Jae Yeon JY Huang Xiaofang X Wang Tse-En TE Lishko Polina V PV Davies Karen M KM Wennemuth Gunther G Nicastro Daniela D Chung Jean-Ju JJ
Nature communications 20220617 1
The sperm calcium channel CatSper plays a central role in successful fertilization as a primary Ca<sup>2+</sup> gateway. Here, we applied cryo-electron tomography to visualize the higher-order organization of the native CatSper complex in intact mammalian sperm. The repeating CatSper units form long zigzag-rows along mouse and human sperm flagella. Above each tetrameric channel pore, most of the extracellular domains form a canopy that interconnects to a zigzag-shaped roof. Murine CatSper contai ...[more]