Unknown

Dataset Information

0

Erythroid Differentiation Regulator 1 Strengthens TCR Signaling by Enhancing PLCγ1 Signal Transduction Pathway.


ABSTRACT: Erythroid differentiation regulator 1 (Erdr1) has previously been reported to control thymocyte selection via TCR signal regulation, but the effect of Erdr1 as a TCR signaling modulator was not studied in peripheral T cells. In this report, it was determined whether Erdr1 affected TCR signaling strength in CD4 T cells. Results revealed that Erdr1 significantly enhanced the anti-TCR antibody-mediated activation and proliferation of T cells while failing to activate T cells in the absence of TCR stimulation. In addition, Erdr1 amplified Ca2+ influx and the phosphorylation of PLCγ1 in CD4 T cells with the TCR stimuli. Furthermore, NFAT1 translocation into nuclei in CD4 T cells was also significantly promoted by Erdr1 in the presence of TCR stimulation. Taken together, our results indicate that Erdr1 positively modulates TCR signaling strength via enhancing the PLCγ1/Ca2+/NFAT1 signal transduction pathway.

SUBMITTER: Kim MS 

PROVIDER: S-EPMC8776247 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC4096552 | biostudies-literature
| S-EPMC6629120 | biostudies-literature
| S-EPMC4605238 | biostudies-other
| S-EPMC4423181 | biostudies-literature
| S-EPMC8772740 | biostudies-literature
| S-EPMC3098487 | biostudies-literature
| S-EPMC1760641 | biostudies-literature
| S-EPMC5476282 | biostudies-literature
| S-EPMC4859592 | biostudies-literature
| S-EPMC7144913 | biostudies-literature