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Commemorative Issue in Honor of Professor Maria Vallet Regi: 20 Years of Silica-Based Mesoporous Materials.

ABSTRACT: This Special Issue entitled "Commemorative Issue in Honor of Professor María Vallet-Regí: 20 Years of Silica-Based Mesoporous Materials" arises from the initiative of the editorial team of Pharmaceutics to pay homage to Professor Maria Vallet-Regí for her ground-breaking pioneering scientific contribution to the field of silica-based mesoporous materials for biomedical applications [...].

SUBMITTER: Colilla M

PROVIDER: S-EPMC8778697 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Pore Narrowing of Mesoporous Silica Materials.

Project description:To use mesoporous silicas as low-k materials, the pore entrances must be really small to avoid diffusion of metals that can increase the dielectric constant of the low-k dielectric. In this paper we present a new method to narrow the pores of mesoporous materials through grafting of a cyclic-bridged organosilane precursor. As mesoporous material, the well-studied MCM-41 powder was selected to allow an easy characterization of the grafting reactions. Firstly, the successful grafting of the cyclic-bridged organosilane precursor on MCM-41 is presented. Secondly, it is demonstrated that pore narrowing can be obtained without losing porosity by removing the porogen template after grafting. The remaining silanols in the pores can then be end-capped with hexamethyl disilazane (HMDS) to make the material completely hydrophobic. Finally, we applied the pore narrowing method on organosilica films to prove that this method is also successful on existing low-k materials.

| S-EPMC5452099 | biostudies-literature

Mesoporous Silica and Titania-Based Materials for Stability Enhancement of Polyphenols.

Project description:To improve phytochemical stability, polyphenolic extracts prepared from Salvia officinalis L., which is a valuable source of phytocompounds with health benefits, were embedded into mesopores of silica, titania, or titania-ceria materials. Ethanolic and hydroalcoholic extracts were prepared by conventional, microwave- or ultrasound-assisted extraction. The influence of the extraction conditions on chemical profile, radical scavenger activity (RSA), and antimicrobial potential of the extracts was assessed. The extracts were characterized by spectrophotometric determination of total polyphenols, flavonoids, chlorophyll pigment contents, as well as RSA. A reverse phase HPLC- PDA analysis was performed for the identification and quantification of extract polyphenols. The extract-loaded materials exhibited an enhanced RSA compared to the free extract after several months of storage, resulting in better polyphenol stability over time following embedding into a mesoporous matrix. Selected extracts free and embedded into mesoporous support were tested against Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922, and Staphylococcus aureus ATCC 25923; the best antimicrobial activity was obtained for S. aureus. A slight improvement in antimicrobial activity was observed for the ethanolic extract prepared by ultrasound-assisted extraction following embedding into the TiO2 matrix compared to MCM-41 silica due to the support contribution.

| S-EPMC8585155 | biostudies-literature

Size-selective pH-operated megagates on mesoporous silica materials.

Project description:pH-responsive megagates have been fabricated around mesoporous silica material SBA-15 in order to mechanize the mesopores. These megagates remain closed in neutral conditions, but open at pH 5. The capping components of the megagates were designed to be capable of controlling pores up to 6.5 nm in diameter. Selectivity of payloads with different sizes can be achieved through the use of different capping components. The operation of the megagates was demonstrated by time-resolved fluorescence spectroscopy which is capable of monitoring the release of both the payload and the cap. This study opens up new possibilities in the field of controllable release.

| S-EPMC3884833 | biostudies-literature

Single Crystal FLIM Characterization of Clofazimine Loaded in Silica-Based Mesoporous Materials and Zeolites.

Project description:Clofazimine (CLZ) is an effective antibiotic used against a wide spectrum of Gram-positive bacteria and leprosy. One of its main drawbacks is its poor solubility in water. Silica based materials are used as drug delivery carriers that can increase the solubility of different hydrophobic drugs. Here, we studied how the properties of the silica framework of the mesoporous materials SBA-15, MCM-41, Al-MCM-41, and zeolites NaX, NaY, and HY affect the loading, stability, and distribution of encapsulated CLZ. Time-correlated single-photon counting (TCSPC) and fluorescence lifetime imaging microscopy (FLIM) experiments show the presence of neutral and protonated CLZ (1.3-3.8 ns) and weakly interacting aggregates (0.4-0.9 ns), along with H- and J-type aggregates (<0.1 ns). For the mesoporous and HY zeolite composites, the relative contribution to the overall emission spectra from H-type aggregates is low (<10%), while for the J-type aggregates it becomes higher (~30%). For NaX and NaY the former increased whereas the latter decreased. Although the CLZ@mesoporous composites show higher loading compared to the CLZ@zeolites ones, the behavior of CLZ is not uniform and its dynamics are more heterogeneous across different single mesoporous particles. These results may have implication in the design of silica-based drug carriers for better loading and release mechanisms of hydrophobic drugs.

| S-EPMC6627708 | biostudies-literature

Dissolution of Mesoporous Silica Supports in Aqueous Solutions: Implications for Mesoporous Silica-based Water Treatment Processes.

Project description:Under pH 7 - 10 conditions, the mesoporous silica supports proposed for use in water treatment are relatively unstable. In batch experiments conducted in pH 7 solutions, the commonly used support SBA-15 dissolved quickly, releasing approximately 30 mg/L of dissolved silica after 2 hours. In column experiments, more than 45% of an initial mass of 0.25 g SBA-15 dissolved within 2 days when a pH 8.5 solution flowed through the column. In a mixed iron oxide/SBA-15 system, the dissolution of SBA-15 changed the iron oxide reactivity toward H(2)O(2) decomposition, because dissolved silica deposited on iron oxide surface and changed its catalytic active sites. As with SBA-15, other mesoporous silica materials including HMS, MCM-41, four types of functionalized SBA-15, and two types of metal oxide-containing SBA-15 also dissolved under circumneutral pH solutions. The dissolution of mesoporous silica materials raises questions about their use under neutral and alkaline pH in aqueous solutions, because silica dissolution might compromise the behavior of the material.

| S-EPMC3465675 | biostudies-literature

Isolation and immobilization of alkaline protease on mesoporous silica and mesoporous ZSM-5 zeolite materials for improved catalytic properties.

Project description:Alkaline protease from brinjal leaf (Solanum melongena) having milk clotting activity has been purified to 9.44 fold to a final specific activity of 45.71 U/mg. SDS-PAGE of the final preparation revealed a single protein band of approx 14 kDa. Purified enzyme was characterized and was successfully immobilized into the amorphous mesoporous silica (SBA-15) and crystalline mesoporous zeolite (Nano-ZSM-5) using entrapment method. Maximum immobilization of 63.5% and 79.77% was obtained with SBA-15 and Nano-ZSM-5, respectively. This protocol serves as a novel approach for bioprocesses, mainly as milk coagulant for local dairy products and particularly, cheese making, and opens the new dimension of further research and other innovation.

| S-EPMC5668643 | biostudies-literature

Efficient Photoacoustic Imaging With Biomimetic Mesoporous Silica-Based Nanoparticles.

Project description:Indocyanine green (ICG), a near-infrared (NIR) fluorescent dye approved by the Food and Drug Administration (FDA), has been extensively used as a photoacoustic (PA) probe for PA imaging. However, its practical application is limited by poor photostability in water, rapid body clearance, and non-specificity. Herein, we fabricated a novel biomimetic nanoprobe by coating ICG-loaded mesoporous silica nanoparticles with the cancer cell membrane (namely, CMI) for PA imaging. This probe exhibited good dispersion, large loading efficiency, good biocompatibility, and homologous targeting ability to Hela cells in vitro. Furthermore, the in vivo and ex vivo PA imaging on Hela tumor-bearing nude mice demonstrated that CMI could accumulate in tumor tissue and display a superior PA imaging efficacy compared with free ICG. All these results demonstrated that CMI might be a promising contrast agent for PA imaging of cervical carcinoma.

| S-EPMC8669651 | biostudies-literature

Silica materials effect on Bhas 42 cell transformation

Project description:Gene expression profile analysis allowed to identify a panel of genes characteristic of silica materials effect on transformation process.

2022-06-01 | GSE133279 | GEO

One-step synthesis of amine-functionalized hollow mesoporous silica nanoparticles as efficient antibacterial and anticancer materials.

Project description:In this study, amine-functionalized hollow mesoporous silica nanoparticles with an average diameter of ?100 nm and shell thickness of ?20 nm were prepared by an one-step process. This new nanoparticulate system exhibited excellent killing efficiency against mycobacterial (M. smegmatis strain mc(2) 651) and cancer cells (A549).

| S-EPMC4334903 | biostudies-literature

Controlled Nutrient Delivery to Pancreatic Islets Using Polydopamine-Coated Mesoporous Silica Nanoparticles

Project description:In the present study, we designed a nanoscale platform for the sustained and controlled delivery of nutrients to pancreatic islets-upon transplantation. Our platform consists of a mesoporous silica nanoparticle (MSNP), loaded with glutamine (G), an essential amino acid required for islet survival and function, and capped with polydopamine (PD). To control the release of glutamine, various concentrations (0.5 - 2 mg/mL) of PD and incubation times (0.5 – 2 h) with MSNPs were investigated in terms of pharmacological properties and biological functions. After extensive testing, PD-G-MSNPs made using PD coating of 0.5 mg/mL incubated for 0.5 h resulted in the optimal platform to maintain the islet viability and functionality in vitro. Following syngeneic renal sub-capsule islet transplantation in STZ-diabetic mice, PD-G-MSNPs improved the engraftment of pancreatic islets as well as their function, resulting in re-establishment of glycemic control. Collectively, our data shows that PD-G-MSNPs can support transplanted islets by providing them with a controlled and sustained supply of nutrients.

2023-12-04 | GSE247020 | GEO

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