Ontology highlight
ABSTRACT:
SUBMITTER: Goldberg Z
PROVIDER: S-EPMC8778890 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Goldberg Zehavit Z Sher Ifat I Qassim Lamis L Chapman Joab J Rotenstreich Ygal Y Shavit-Stein Efrat E
International journal of molecular sciences 20220117 2
The aim of this study was to characterize the distribution of the thrombin receptor, protease activated receptor 1 (PAR1), in the neuroretina. Neuroretina samples of wild-type C57BL/6J and PAR1<sup>-/-</sup> mice were processed for indirect immunofluorescence and Western blot analysis. Reverse transcription quantitative real-time PCR (RT-qPCR) was used to determine mRNA expression of coagulation Factor X (FX), prothrombin (PT), and PAR1 in the isolated neuroretina. Thrombin activity following KC ...[more]