Ontology highlight
ABSTRACT:
SUBMITTER: McLaughlin JN
PROVIDER: S-EPMC1838494 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
McLaughlin Joseph N JN Patterson Myla M MM Malik Asrar B AB
Proceedings of the National Academy of Sciences of the United States of America 20070321 13
Thrombin activates endothelial cell signaling by cleaving the protease-activated receptor-1 (PAR1). However, the function of the apparently nonsignaling receptor PAR3 also expressed in endothelial cells is unknown. We demonstrate here the crucial role of PAR3 in potentiating the responsiveness of PAR1 to thrombin. We tested the hypothesis that PAR1/PAR3 heterodimerization and its effect in modifying G protein selectivity was responsible for PAR3 regulation of PAR1 sensitivity. Using bioluminesce ...[more]